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Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions?
Ren, Jiaojiao; Wang, Zhenghe; Zhang, Yujie; Zhang, Peidong; Zhou, Jianmeng; Zhong, Wenfang; Wang, Xing; Gao, Pingming; Shi, Xiaoming; Mao, Chen.
Afiliación
  • Ren J; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, China.
  • Wang Z; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhang Y; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhang P; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhou J; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhong W; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Wang X; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
  • Gao P; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, China.
  • Shi X; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, China.
  • Mao C; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Front Public Health ; 9: 787935, 2021.
Article en En | MEDLINE | ID: mdl-34912772
Introduction: The association patterns of hemoglobin (HB) concentrations with mortality among the longevity older adults are unclear. We aimed to evaluate the relationship among older adults form Chinese longevity regions. Methods: We included 1,785 older adults aged ≥65 years (mean age, 86.7 years; 1,002 women, 783 men) from the community-based Chinese Longitudinal Healthy Longevity Survey. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality using multivariable Cox proportional hazards models and Cox models with restricted cubic spline. Results: In total, 999 deaths occurred during a median follow-up of 5.4 years from 2011 to 2017. Restricted cubic spline analysis found no non-linear association between HB concentrations and all-cause mortality after a full adjustment for covariates among the older adults form longevity regions (p > 0.05 for non-linearity). The risk for all-cause mortality was significantly higher in the groups with HB concentration of <11.0 g/dL (HR: 1.37, 95% CI: 1.10-1.70) and 11.0-12.0 g/dL (HR: 1.25, 95% CI: 1.01-1.54); the risk of all-cause mortality was significantly lower in the groups with HB concentration ≥14.0 g/dL (HR: 0.76, 95% CI: 0.60-0.97) compared with the reference group (13.0-13.9 g/dL). Conclusions: Among older adults form Chinese longevity regions, HB concentrations were found to be inversely and linearly associated with all-cause mortality. Further prospective intervention trials are needed to confirm whether higher HB concentrations had a lower risk of mortality in these older adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemoglobinas / Pueblo Asiatico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Front Public Health Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemoglobinas / Pueblo Asiatico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Front Public Health Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza