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Raw and Wine Processed Schisandra chinensis Regulate NREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by Modulating HPA Axis.
Su, Dan; Luo, Jian; Ge, Junqi; Liu, Yali; Jin, Chen; Xu, Pengfei; Zhang, Ruowen; Zhu, Genhua; Yang, Ming; Ai, Zhifu; Song, Yonggui.
Afiliación
  • Su D; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Luo J; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Ge J; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Liu Y; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Jin C; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Xu P; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Zhang R; Shenzhen Honsan Health Industry Group, Shenzhen, China.
  • Zhu G; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Yang M; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Ai Z; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
  • Song Y; Key Laboratory of depression animal model based on TCM syndrome, Jiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM for prevention and treatment of brain diseases with cognitive impairment, Jiangxi Province, Jiangxi University of Chinese Medicine, Nanchang, China.
Planta Med ; 88(14): 1311-1324, 2022 Nov.
Article en En | MEDLINE | ID: mdl-34911135
Clinical studies have shown that insomnia and anxiety are usually accompanied by cardiovascular dysfunction. In traditional Chinese medicine, Schisandra chinensis (SC) and wine processed Schisandra chinensis (WSC) are mainly used for the treatment of dysphoria, palpitation and insomnia. However, little attention was paid to its mechanism. In this study, we monitored the effect of SC and WSC on the nervous system and cardiovascular system of free-moving rats in the real-time. Our results show that SC and WSC can alleviate cardiovascular dysfunction while promoting sleep, and we further explored their potential mechanisms. HPLC-QTOF-MS was used for the quality control of chemical components in SC and WSC. Data sciences international (DSI) physiological telemetry system was applied to collect the electroencephalogram (EEG), electrocardiogram (ECG) and other parameters of free-moving rats to understand the effects of long-term intake of SC and WSC on rats. The content of Cortisol (CORT), neurotransmitters and amino acids in rat pituitary and hypothalamus were analyzed by UPLC-MS to determine the activity of HPA axis. The expression of melatonin receptor MT1 was analyzed by immunofluorescence technique. Our results suggested that SC and WSC may play the role of promoting sleep by increasing the expression level of melatonin receptor MT1 in hypothalamus, and modulate the activity of HPA axis by regulating the levels of the related neurotransmitters and amino acid, so as to improve the abnormal cardiovascular system of rats. This study may provide theoretical support for explicating the advantages of SC and other phytomedicines in the treatment of insomnia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vino / Schisandra / Trastornos del Inicio y del Mantenimiento del Sueño Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Planta Med Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vino / Schisandra / Trastornos del Inicio y del Mantenimiento del Sueño Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Planta Med Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania