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Incidence of Herpes Simplex Virus Type 2 Infection Among African Women Using Depot Medroxyprogesterone Acetate, a Copper Intrauterine Device, or a Levonorgestrel Implant for Contraception: A Nested Randomized Trial.
Mugo, Nelly R; Stalter, Randy M; Heffron, Renee; Rees, Helen; Scoville, Caitlin W; Morrison, Charles; Kourtis, Athena P; Bukusi, Elizabeth; Beksinka, Mags; Philip, Neena M; Beesham, Ivana; Deese, Jen; Edward, Vinodh; Donnell, Deborah; Baeten, Jared M.
Afiliación
  • Mugo NR; Center for Clinical Research & Center for Microbiology Kenya Medical Research Institute (KEMRI), Kenya.
  • Stalter RM; Department of Global Health, Seattle, Washington, USA.
  • Heffron R; Department of Global Health, Seattle, Washington, USA.
  • Rees H; Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Scoville CW; Department of Global Health, Seattle, Washington, USA.
  • Morrison C; Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Kourtis AP; University of the Witwatersrand, Wits Reproductive Health and HIV Institute (Wits RHI), Johannesburg, South Africa.
  • Bukusi E; Department of Global Health, Seattle, Washington, USA.
  • Beksinka M; Behavioral, Epidemiologic and Clinical Sciences, FHI 360, Durham, North Carolina, USA.
  • Philip NM; Division of HIV Prevention, National Center for HIV, Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Beesham I; Center for Clinical Research & Center for Microbiology Kenya Medical Research Institute (KEMRI), Kenya.
  • Deese J; Department of Global Health, Seattle, Washington, USA.
  • Edward V; MatCH Research Unit (MRU), Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa.
  • Donnell D; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Baeten JM; MatCH Research Unit (MRU), Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa.
Clin Infect Dis ; 75(4): 586-595, 2022 09 10.
Article en En | MEDLINE | ID: mdl-34910143
BACKGROUND: Globally, women have higher herpes simplex virus type 2 (HSV-2) prevalence than men; data from observational studies suggest a possible association of HSV-2 acquisition with use of intramuscular depot medroxyprogesterone acetate (DMPA-IM). METHODS: Within a randomized trial of the effect of 3 contraceptive methods-DMPA-IM, a copper intrauterine device (IUD), and a levonorgestrel (LNG) implant-on human immunodeficiency virus (HIV) acquisition, we assessed HSV-2 acquisition. HSV-2 and HIV seronegative women, aged 16-35 years, and seeking effective contraception were followed for 12-18 months at 12 sites in Eswatini, Kenya, South Africa, and Zambia from 2015 to 2018. HSV-2 serologic testing was done at enrollment and final study visits. Intention-to-treat analysis using Poisson regression with robust standard errors compared HSV-2 incidence by contraceptive method. RESULTS: At baseline, 4062 randomized women were HSV-2 seronegative, of whom 3898 (96.0%) had a conclusive HSV-2 result at their final study visit. Of these, 614 (15.8%) acquired HSV-2, at an incidence of 12.4/100 person-years (p-y): 10.9/100 p-y among women assigned DMPA-IM, 13.7/100 p-y the copper IUD, and 12.7/100 p-y the LNG implant. Incidence rate ratios (IRR) for HSV-2 acquisition were 0.80 (95% confidence interval [CI], .65-.97) for DMPA-IM compared with copper IUD, 0.86 (95% CI, .71-1.05) for DMPA-IM compared with LNG implant, and 1.08 (95% CI, .89-1.30) for copper IUD compared with LNG implant. HSV-2 acquisition risk was significantly increased among women who also acquired HIV during follow-up (IRR 3.55; 95% CI, 2.78-4.48). CONCLUSIONS: In a randomized trial, we found no association between HSV-2 acquisition and use of 3 contraceptive methods. TRIAL REGISTRATION: ClinicalTrials.gov number NCT02550067.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Anticonceptivos Femeninos / Herpes Simple / Dispositivos Intrauterinos de Cobre Tipo de estudio: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: Kenia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Anticonceptivos Femeninos / Herpes Simple / Dispositivos Intrauterinos de Cobre Tipo de estudio: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article País de afiliación: Kenia Pais de publicación: Estados Unidos