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Advanced ankylosing spondylitis: a multisite, multimodality densitometric analysis for investigation of bone loss in the axial and appendicular skeleton.
Theodorou, Stavroula; Theodorou, Daphne; Kakitsubata, Yousuke; Gelalis, Ioannis; Tsifetaki, Niki.
Afiliación
  • Theodorou S; University Hospital of Ioannina, Department of Radiology - Ioannina, Greece.
  • Theodorou D; General Hospital of Ioannina G. Hatzikosta, Department of Radiology - Ioannina, Greece.
  • Kakitsubata Y; Miyazaki Konan Hospital, Department of Radiology and Bone Metabolism - Miyazaki, Japan.
  • Gelalis I; University Hospital of Ioannina, Department of Orthopaedic Surgery - Ioannina, Greece.
  • Tsifetaki N; General Hospital of Ioannina, Rheumatology Clinic, Department of Internal Medicine - Ioannina, Greece.
Rev Assoc Med Bras (1992) ; 67(11): 1627-1632, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34909889
OBJECTIVE: The aim of this study was to investigate if there is a bias in bone mineral density measurements among major densitometric techniques across multiple skeletal sites. METHODS: In 25 advanced ankylosing spondylitis patients, bone mineral density measurements were acquired in the lumbar spine, the hip, and the forearm. RESULTS: In total, 60% of patients had a bone mineral density Z-score of -2 or less at one or more skeletal sites. Dedicated loss of cortical bone was identified at the distal forearm (60% of patients). Differences in bone mineral density measurements across all densitometric techniques were highly significant (p≤0.001). Bone loss was more striking in spinal trabecular bone by three-dimensional quantitative computed tomography [Z-score -2.1] versus dual-energy X-ray absorptiometry [Z-score 0]. A trabecular bone loss quantified by quantitative computed tomography was about twice as much as a cortical bone loss by single-energy X-ray absorptiometry (p=0.001). CONCLUSIONS: Low bone mineral density is prevalent in advanced ankylosing spondylitis patients, predominating in the spine. Bone mineral density measurements have systematic differences when compared to each other. Knowledge of these offsets is useful for improved diagnosis of regional bone loss that allows for targeted treatment of osteoporosis. Three-dimensional quantitative computed tomography is more suitable for evaluating spinal osteoporosis in advanced ankylosing spondylitis than dual-energy X-ray absorptiometry, which rather underestimates bone loss.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Enfermedades Óseas Metabólicas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Enfermedades Óseas Metabólicas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Año: 2021 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Brasil