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Rapid diagnostic tests in the management of pneumonia.
Riccobono, Eleonora; Bussini, Linda; Giannella, Maddalena; Viale, Pierluigi; Rossolini, Gian Maria.
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  • Riccobono E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Bussini L; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Giannella M; Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant' Orsola, Bologna, Italy.
  • Viale P; Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant' Orsola, Bologna, Italy.
  • Rossolini GM; Infectious Diseases Unit, Department of Medical and Surgical Sciences, Policlinico Sant' Orsola, Bologna, Italy.
Expert Rev Mol Diagn ; 22(1): 49-60, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34894965
INTRODUCTION: Pneumonia is one of the main causes of mortality associated with infectious diseases worldwide. Several challenges have been identified in the management of patients with pneumonia, ranging from accurate and cost-effective microbiological investigations, prompt and adequate therapeutic management, and optimal treatment duration. AREAS COVERED: In this review, an updated summary on the current management of pneumonia patients is provided and the epidemiological issues of infectious respiratory diseases, which in the current pandemic situation are of particular concern, are addressed. The clinical and microbiological approaches to pneumonia diagnosis are reviewed, including discussion about the new molecular assays pointing out both their strengths and limitations. Finally, the current recommendations about antibiotic treatment are examined and discussed depending on the epidemiological contexts, including those with high prevalence of multidrug-resistant bacteria. EXPERT OPINION: We claim that rapid diagnostic tests, if well-positioned in the diagnostic workflow and reserved for the subset of patients who could most benefit from these technologies, may represent an interesting and feasible tool to optimize timing of targeted treatments especially in terms of early de-escalation or discontinuation of antibiotic therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Pruebas Diagnósticas de Rutina Tipo de estudio: Diagnostic_studies / Guideline / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Expert Rev Mol Diagn Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Pruebas Diagnósticas de Rutina Tipo de estudio: Diagnostic_studies / Guideline / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Expert Rev Mol Diagn Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido