Recombinant Destabilase from <i>Hirudo medicinalis</i> Is Able to Dissolve Human Blood Clots In Vitro.

Bobrovsky, Pavel; Manuvera, Valentin; Baskova, Izolda; Nemirova, Svetlana; Medvedev, Alexandr; Lazarev, Vassili

Recombinant Destabilase from Hirudo medicinalis Is Able to Dissolve Human Blood Clots In Vitro.

Bobrovsky, Pavel; Manuvera, Valentin; Baskova, Izolda; Nemirova, Svetlana; Medvedev, Alexandr; Lazarev, Vassili.

Afiliación

Bobrovsky P; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Manuvera V; Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Baskova I; Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.
Nemirova S; Federal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Medvedev A; Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, Russia.
Lazarev V; Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, Russia.

Curr Issues Mol Biol ; 43(3): 2068-2081, 2021 Nov 20.

Article en En | MEDLINE | ID: mdl-34889897

Asunto(s)

Endopeptidasas/farmacología; Fibrinolíticos/farmacología; Hirudo medicinalis/enzimología; Proteínas Recombinantes/farmacología; Animales; Coagulación Sanguínea/efectos de los fármacos; Pruebas de Coagulación Sanguínea; Relación Dosis-Respuesta a Droga; Endopeptidasas/metabolismo; Activación Enzimática; Factor XIII/metabolismo; Fibrinolíticos/metabolismo; Humanos; Técnicas In Vitro; Trombosis/tratamiento farmacológico

Palabras clave

blood clot; destabilase; factor XIII; fibrin; isopeptide bond; leech; thrombolysis; thrombolytic drug; thrombosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endopeptidasas / Proteínas Recombinantes / Hirudo medicinalis / Fibrinolíticos Límite: Animals / Humans Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza

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