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Anxiety severity and cognitive function in primary care patients with anxiety disorder: a cross-sectional study.
Nyberg, Jenny; Henriksson, Malin; Wall, Alexander; Vestberg, Torbjörn; Westerlund, Maria; Walser, Marion; Eggertsen, Robert; Danielsson, Louise; Kuhn, H Georg; Åberg, N David; Waern, Margda; Åberg, Maria.
Afiliación
  • Nyberg J; Section for Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 436, SE-405 30, Gothenburg, Sweden. jenny.nyberg@neuro.gu.se.
  • Henriksson M; Region Västra Götaland, Neurology Clinic, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden. jenny.nyberg@neuro.gu.se.
  • Wall A; School of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 454, SE-405 30, Gothenburg, Sweden.
  • Vestberg T; Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 428, SE-405 30, Gothenburg, Sweden.
  • Westerlund M; Region Västra Götaland, Department of Acute Medicine and Geriatrics, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden.
  • Walser M; Department of Clinical Neuroscience, Karolinska Institutet, K8 Clinical Neuroscience, K8 Neuro Ingvar, SE-171 77, Stockholm, Sweden.
  • Eggertsen R; Region Västra Götaland, Regionhälsan, Gothenburg, Sweden.
  • Danielsson L; Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 428, SE-405 30, Gothenburg, Sweden.
  • Kuhn HG; Region Västra Götaland, Department of Acute Medicine and Geriatrics, Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden.
  • Åberg ND; School of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 454, SE-405 30, Gothenburg, Sweden.
  • Waern M; R&D Centre Gothenburg and Södra Bohuslän, Kungsgatan 12, SE-411 19, Gothenburg, Sweden.
  • Åberg M; Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 455, SE-405 30, Gothenburg, Sweden.
BMC Psychiatry ; 21(1): 617, 2021 12 09.
Article en En | MEDLINE | ID: mdl-34886841
BACKGROUND: Deficits in cognitive performance are reported in patients with anxiety disorders, but research is limited and inconsistent. We aimed to investigate cross-sectional associations between cognitive function, with focus on executive function, and anxiety severity in primary care patients diagnosed with anxiety disorders. METHODS: 189 Swedish patients aged 18-65 years (31% men) with anxiety disorders diagnosed according to Mini International Neuropsychiatric Interview were included. Severity of anxiety was assessed using Beck Anxiety Inventory self-assessment scale. Digit span, block design and matrix reasoning tests from the Wechsler Adult Intelligence Scale IV, and the design fluency test from the Delis-Kaplan Executive Function System were used. Multivariable linear regression models were applied to investigate the relationship of anxiety severity and cognitive functioning. Comparisons were also performed to a normed non-clinical population, using the Wilcoxon signed rank test. RESULTS: More severe anxiety was associated with lower digit span test scores (R2 = 0.109, B = -0.040, p = 0.018), but not with block design, matrix reasoning or design fluency tests scores, after adjustment for comorbid major depression in a multivariable model. When compared to a normed population, patients with anxiety performed significantly lower on the block design, digit span forward, digit span sequencing and matrix reasoning tests. CONCLUSIONS: Severity of anxiety among patients with anxiety disorder was associated with executive functions related to working memory, independently of comorbid major depression, but not with lower fluid intelligence. A further understanding of the executive behavioral control in patients with anxiety could allow for more tailored treatment strategies including medication, therapy and interventions targeted to improve specific cognitive domains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cognición / Trastorno Depresivo Mayor Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cognición / Trastorno Depresivo Mayor Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido