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[Association between polymorphism of CASP and NOX3 with risk of noise-induced hearing loss].
Xin, J R; Chen, Y Q; Liu, S Y; Qian, P Y; Zhao, T Y; Wang, H Y; Zhang, M B; Yang, L.
Afiliación
  • Xin JR; School of Public Health, Hangzhou Normal University, Hangzhou 310016, China.
  • Chen YQ; School of Public Health, Hangzhou Normal University, Hangzhou 310016, China.
  • Liu SY; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Qian PY; School of Public Health, Hangzhou Normal University, Hangzhou 310016, China.
  • Zhao TY; Zhanjiang Central People's Hospital, Zhanjiang 524038, China.
  • Wang HY; School of Public Health, Hangzhou Normal University, Hangzhou 310016, China.
  • Zhang MB; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
  • Yang L; School of Public Health, Hangzhou Normal University, Hangzhou 310016, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi ; 39(11): 819-824, 2021 Nov 20.
Article en Zh | MEDLINE | ID: mdl-34886640
Objective: To explore the effect of gene polymorphism on workers suffering from noise induced hearing loss (NIHL) . Methods: In May 2019, a case-control study was conducted to select noise exposed workers in five factories in Zhejiang Province from 2017 to 2018. The average hearing threshold of binaural high frequency (3, 4, 6 kHz) was >25 dB (A) as the NIHL group, and the hearing threshold of any language frequency (0.5, 1, 2 kHz) was ≤25 dB (A) as the non NIHL group, with 307 people in each group. The general demographic data, occupational history, pure tone audiometry results and oral swab mucosal samples of noise exposed workers were collected, and the DNA of oral mucosal cells was extracted. The relationship between genetic risk score (GRS) and NIHL was analyzed, single nucleotide polymorphisms (SNP) were genotyped, the relationship between genotype and NIHL was analyzed by logistic regression, and the relationship between haplotype and NIHL was analyzed by R language. Results: After adjusting for gender, age, education and working years, the risk of NIHL among workers carrying cysteine-aspartic acid protease 3 gene (CASP3) rs1049216 recessive model GG genotype, rs6948 recessive model TT genotype, NADPH oxidase 3 gene (NOX3) rs12195525 additive model GT genotype and dominant model TT+GT genotype decreased (P<0.05) , the risk of disease was higher in workers with AA genotype carrying cysteine-aspartic acid protease 7 gene (CASP7) rs12415607 additive model (P<0.05) . There was a strong linkage disequilibrium (LD) relationship between rs1049216 and rs6948 (D'>0.8) . Haplotype AT and GG composed of rs1049216-rs6948 increased the risk of NIHL (P<0.05) . The risk of NIHL increased with the increase of GRS (OR=2.69, P<0.05) . Conclusion: Genotype polymorphisms at rs1049216 and rs6948 (CASP3) , rs12195525 (NOX3) , rs12415607 (CASP7) may be associated with susceptibility to NIHL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida Auditiva Provocada por Ruido / Ruido en el Ambiente de Trabajo Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: Zh Revista: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Asunto de la revista: MEDICINA OCUPACIONAL Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida Auditiva Provocada por Ruido / Ruido en el Ambiente de Trabajo Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: Zh Revista: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Asunto de la revista: MEDICINA OCUPACIONAL Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China