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Somatic mitochondrial DNA mutations in different grades of glioma.
Soon, Bee Hong; Abu, Nadiah; Abdul Murad, Nor Azian; Then, Sue-Mian; Abu Bakar, Azizi; Fadzil, Farizal; Thanabalan, Jegan; Mohd Haspani, Mohd Saffari; Toh, Charng Jeng; Kumar, Ramesh; Jaafar, Ainul Syahrilfazli; Mohd Azli, Anis Nabillah; Mohd Azahar, Mohd Syakir; Paramasvaran, Sanmugarajah; Palaniandy, Kamalanathan; Mohd Tamil, Azmi; Jamal, Rahman.
Afiliación
  • Soon BH; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Abu N; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Abdul Murad NA; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Then SM; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Abu Bakar A; UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Fadzil F; The University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia.
  • Thanabalan J; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Mohd Haspani MS; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Toh CJ; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Kumar R; Department of Neurosurgery, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
  • Jaafar AS; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Mohd Azli AN; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Mohd Azahar MS; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Paramasvaran S; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Palaniandy K; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Mohd Tamil A; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
  • Jamal R; Neurosurgery Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
Per Med ; 19(1): 25-39, 2022 01.
Article en En | MEDLINE | ID: mdl-34873928
Aim: Mitochondrial DNA (mtDNA) alterations play an important role in the multistep processes of cancer development. Gliomas are among the most diagnosed brain cancer. The relationship between mtDNA alterations and different grades of gliomas are still elusive. This study aimed to elucidate the profile of somatic mtDNA mutations in different grades of gliomas and correlate it with clinical phenotype. Materials & methods: Forty histopathologically confirmed glioma tissue samples and their matched blood were collected and subjected for mtDNA sequencing. Results & conclusion: About 75% of the gliomas harbored at least one somatic mutation in the mtDNA gene, and 45% of these mutations were pathogenic. Mutations were scattered across the mtDNA genome, and the commonest nonsynonymous mutations were located at complex I and IV of the mitochondrial respiratory chain. These findings may have implication for future research to determine the mitochondrial energetics and its downstream metabolomics on gliomas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Mitocondrial / Glioma Límite: Humans Idioma: En Revista: Per Med Año: 2022 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Mitocondrial / Glioma Límite: Humans Idioma: En Revista: Per Med Año: 2022 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido