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Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms.
Ghasemi, Maedeh; Navidhamidi, Mojdeh; Rezaei, Fatemeh; Azizikia, Armin; Mehranfard, Nasrin.
Afiliación
  • Ghasemi M; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Navidhamidi M; Department of Medical-Surgical Nursing and Basic Sciences, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
  • Rezaei F; Department of Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran.
  • Azizikia A; Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mehranfard N; Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Shafa Street, Urmia, 57157-89400, Iran. mehranfard_n@yahoo.com.
Cogn Affect Behav Neurosci ; 22(3): 431-449, 2022 06.
Article en En | MEDLINE | ID: mdl-34873665
The hippocampus has been implicated in modulating anxiety. It interacts with a variety of brain regions, both cortical and subcortical areas regulating emotion and stress responses, including prefrontal cortex, amygdala, hypothalamus, and the nucleus accumbens, to adjust anxiety levels in response to a variety of stressful conditions. Growing evidence indicates that anxiety is associated with increased neuronal excitability in the hippocampus, and alterations in local regulation of hippocampal excitability have been suggested to underlie behavioral disruptions characteristic of certain anxiety disorders. Furthermore, studies have shown that some anxiolytics can treat anxiety by altering the excitability and plasticity of hippocampal neurons. Hence, identifying cellular and molecular mechanisms and neural circuits that regulate hippocampal excitability in anxiety may be beneficial for developing targeted interventions for treatment of anxiety disorders particularly for the treatment-resistant cases. We first briefly review a role of the hippocampus in fear. We then review the evidence indicating a relationship between the hippocampal activity and fear/anxiety and discuss some possible mechanisms underlying stress-induced hippocampal excitability and anxiety-related behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipocampo / Neuronas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cogn Affect Behav Neurosci Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipocampo / Neuronas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cogn Affect Behav Neurosci Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos