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Relationship between sensory characteristics and cortical thickness/volume in autism spectrum disorders.
Habata, Kaie; Cheong, Yongjeon; Kamiya, Taku; Shiotsu, Daichi; Omori, Ichiro M; Okazawa, Hidehiko; Jung, Minyoung; Kosaka, Hirotaka.
Afiliación
  • Habata K; Department of Neuropsychiatry, University of Fukui, Eiheiji, Fukui, Japan.
  • Cheong Y; Cognitive Science Research Group, Korea Brain Research Institute, Daegu, South Korea.
  • Kamiya T; Department of Neuropsychiatry, University of Fukui, Eiheiji, Fukui, Japan.
  • Shiotsu D; Department of Neuropsychiatry, University of Fukui, Eiheiji, Fukui, Japan.
  • Omori IM; Department of Neuropsychiatry, University of Fukui, Eiheiji, Fukui, Japan.
  • Okazawa H; Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui, Japan.
  • Jung M; Research Center for Child Mental Development, University of Fukui, Eiheiji, Fukui, Japan.
  • Kosaka H; Division of Developmental Higher Brain Functions, Department of Child Development, United Graduate School of Child Development, University of Fukui, Japan, Eiheiji, Fukui, Japan.
Transl Psychiatry ; 11(1): 616, 2021 12 06.
Article en En | MEDLINE | ID: mdl-34873147
Individuals with autism spectrum disorders (ASDs) exhibit atypical sensory characteristics, impaired social skills, deficits in verbal and nonverbal communication, and restricted and repetitive behaviors. The relationship between sensory characteristics and brain morphological changes in ASD remains unclear. In this study, we investigated the association between brain morphological changes and sensory characteristics in individuals with ASD using brain image analysis and a sensory profile test. Forty-three adults with ASD and 84 adults with typical development underwent brain image analysis using FreeSurfer. The brain cortex was divided into 64 regions, and the cortical thickness and volume of the limbic system were calculated. The sensory characteristics of the participants were evaluated using the Adolescent/Adult Sensory Profile (AASP). Correlation analysis was performed for cortical thickness, limbic area volume, and AASP scores. In the ASD group, there was a significant positive correlation between visual sensory sensitivity scores and the right lingual cortical thickness (r = 0.500). There were also significant negative correlations between visual sensation avoiding scores and the right lateral orbitofrontal cortical thickness (r = -0.513), taste/smell sensation avoiding scores and the right hippocampal volume (r = -0.510), and taste/smell sensation avoiding scores and the left hippocampal volume (r = -0.540). The study identified associations among the lingual cortical thickness, lateral orbitofrontal cortical thickness, and hippocampal volume and sensory characteristics. These findings suggest that brain morphological changes may trigger sensory symptoms in adults with ASD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Transl Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Transl Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos