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Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels.
Vavasour, I M; Becquart, P; Gill, J; Zhao, G; Yik, J T; Traboulsee, A; Carruthers, R L; Kolind, S H; Schabas, A J; Sayao, A L; Devonshire, V; Tam, R; Moore, G R W; Stukas, S; Wellington, C L; Quandt, J A; Li, D K B; Laule, C.
Afiliación
  • Vavasour IM; Radiology, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: lees@physics.ubc.ca.
  • Becquart P; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Gill J; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Zhao G; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada.
  • Yik JT; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; Physics & Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.
  • Traboulsee A; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Carruthers RL; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kolind SH; Radiology, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; Medicine
  • Schabas AJ; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Sayao AL; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Devonshire V; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Tam R; Radiology, University of British Columbia, Vancouver, British Columbia, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
  • Moore GRW; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Can
  • Stukas S; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Wellington CL; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Quandt JA; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Li DKB; Radiology, University of British Columbia, Vancouver, British Columbia, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Laule C; Radiology, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Ca
Mult Scler Relat Disord ; 57: 103422, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34871858
We characterized the frequency of diffusely abnormal white matter (DAWM) across a broad spectrum of multiple sclerosis (MS) participants. 35% of clinically isolated syndrome (CIS), 57% of relapsing remitting and 64% of secondary progressive MS participants demonstrated DAWM. CIS with DAWM had decreased cortical thickness, higher lesion load and a higher concentration of serum neurofilament light chain compared to CIS without DAWM. DAWM may be useful in identifying CIS patients with greater injury to their brains. Larger and longitudinal studies are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Recurrente-Remitente / Sustancia Blanca / Esclerosis Múltiple Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mult Scler Relat Disord Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple Recurrente-Remitente / Sustancia Blanca / Esclerosis Múltiple Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mult Scler Relat Disord Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos