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Impact of Dapivirine and Placebo Vaginal Rings on the Microbiota of Adolescent, Lactating, and Postmenopausal Females.
Austin, Michele N; Meyn, Leslie A; Avolia, Hilary A; Petrina, Melinda A; Cosentino, Lisa A; Alphonse, Calins; Chen, Beatrice A; Bunge, Katherine; Noguchi, Lisa; Beigi, Richard; Squires, Kathleen; Hillier, Sharon L.
Afiliación
  • Austin MN; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
  • Meyn LA; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
  • Avolia HA; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Petrina MA; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
  • Cosentino LA; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
  • Alphonse C; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
  • Chen BA; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Bunge K; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.
  • Noguchi L; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Beigi R; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Squires K; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Hillier SL; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Infect Dis ; 225(12): 2208-2218, 2022 06 15.
Article en En | MEDLINE | ID: mdl-34865071
BACKGROUND: A 25-mg dapivirine vaginal ring has been demonstrated to reduce risk of human immunodeficiency virus (HIV) acquisition in nonpregnant adult women. In this secondary analysis of studies conducted in US adolescent, lactating, and postmenopausal females, vaginal microbiota was assessed prior to and after ring use, and between dapivirine and placebo ring users. METHODS: Vaginal fluid swabs were collected before and after product use for the evaluation of microbiota using Nugent criteria, quantitative culture, and quantitative polymerase chain reaction. RESULTS: Vaginal ring use did not impact bacterial vaginosis prevalence among the 3 populations and was associated with minimal shifts in microbiota. Adolescents in both arms demonstrated an increased prevalence of Lactobacillus crispatus and a decrease in quantity of Megasphaera lornae. Postmenopausal active and placebo ring users demonstrated an increased prevalence of lactobacilli and non-albicans yeast, while dapivirine ring users demonstrated an increased prevalence of Candida albicans and increased quantity of group B Streptococcus and non-albicans yeasts. Prevotella species were increased in lactating women, whereas Prevotella timonensis increased in prevalence and concentration among adolescent and postmenopausal females and Prevotella bivia increased in prevalence among adolescent dapivirine ring users. CONCLUSIONS: Dapivirine vaginal ring use was associated with minimal changes in the vaginal microbiota that are likely not clinically significant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos Anticonceptivos Femeninos / Microbiota Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos Anticonceptivos Femeninos / Microbiota Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos