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Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age.
Da Silva Sena, Carla Rebeca; de Queiroz Andrade, Ediane; de Gouveia Belinelo, Patricia; Percival, Elizabeth; Prangemeier, Benjamin; O'Donoghue, Christopher; Terry, Sandrine; Burke, Tanya; Gunning, William; Murphy, Vanessa E; Robinson, Paul D; Sly, Peter D; Gibson, Peter G; Collison, Adam M; Mattes, Joerg.
Afiliación
  • Da Silva Sena CR; Priority Research Centre GrowUpWell, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • de Queiroz Andrade E; Priority Research Centre GrowUpWell, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • de Gouveia Belinelo P; Priority Research Centre GrowUpWell, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • Percival E; Priority Research Centre GrowUpWell, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • Prangemeier B; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
  • O'Donoghue C; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Terry S; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Burke T; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Gunning W; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Murphy VE; Priority Research Centre GrowUpWell, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • Robinson PD; Respiratory Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
  • Sly PD; Queensland Children's Medical Research Institute, University of Queensland, Herston, Queensland, Australia.
  • Gibson PG; Priority Research Centre Healthy Lungs, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • Collison AM; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia.
  • Mattes J; Priority Research Centre GrowUpWell, The University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Thorax ; 77(11): 1106-1112, 2022 11.
Article en En | MEDLINE | ID: mdl-34862324
BACKGROUND: Nitric oxide in exhaled air (eNO) is used as a marker of type 2 immune response-induced airway inflammation. We aimed to investigate the association between eNO and bronchiolitis incidence and respiratory symptoms in infancy, and its correlation with eosinophil protein X (EPX). METHODS: We followed up infants at 6 weeks of age born to mothers with asthma in pregnancy and measured eNO during natural sleep using a rapid response chemiluminescense analyser (CLD88; EcoMedics), collecting at least 100 breaths, interpolated for an expiratory flow of 50 mL/s. EPX normalised to creatinine was measured in urine samples (uEPX/c). A standardised questionnaire was used to measure symptoms in first year of life. Associations were investigated using multiple linear regression and robust Poisson regression models. RESULTS: eNO levels were obtained in 184 infants, of whom 125/184 (68%) had 12 months questionnaire data available and 51/184 (28%) had uEPX/c measured. Higher eNO was associated with less respiratory symptoms during the first 6 weeks of life (n=184, ß-coefficient: -0.49, 95% CI -0.95 to -0.04, p=0.035). eNO was negatively associated with uEPX/c (ß-coefficient: -0.004, 95% CI -0.008 to -0.001, p=0.021). Risk incidence of bronchiolitis, wheeze, cold or influenza illness and short-acting beta-agonist use significantly decreased by 18%-24% for every unit increase in eNO ppb. CONCLUSION: Higher eNO levels at 6 weeks of age may be a surrogate for an altered immune response that is associated with less respiratory symptoms in the first year of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiolitis / Óxido Nítrico Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Infant / Pregnancy Idioma: En Revista: Thorax Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiolitis / Óxido Nítrico Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Infant / Pregnancy Idioma: En Revista: Thorax Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido