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Post-Progression Survival Highly Influences Overall Survival in Driver Gene Mutation/Translocation Negative or Unknown Type of Non-Small Cell Lung Cancer.
Imai, Hisao; Onozato, Ryoichi; Kaira, Kyoichi; Kawashima, Sayaka; Masubuchi, Ken; Tajima, Kohei; Minato, Koichi.
Afiliación
  • Imai H; Division of Respiratory Medicine, Gunma Prefectural Cancer Center, Ota, Japan.
  • Onozato R; Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Kaira K; Division of Thoracic Surgery, Gunma Prefectural Cancer Center, Ota, Japan.
  • Kawashima S; Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Japan.
  • Masubuchi K; Division of Pharmacy, Gunma Prefectural Cancer Center, Ota, Japan.
  • Tajima K; Division of Respiratory Medicine, Gunma Prefectural Cancer Center, Ota, Japan.
  • Minato K; Division of Thoracic Surgery, Gunma Prefectural Cancer Center, Ota, Japan.
Oncology ; 100(2): 89-100, 2022.
Article en En | MEDLINE | ID: mdl-34844253
INTRODUCTION: In stage I-III non-small cell lung cancer (NSCLC), which is considered operable, surgical resection is the most efficacious treatment and is considered to provide a cure. However, after complete surgical resection, approximately 50% of patients with stage I-IIIA NSCLC experience recurrence and death. Once postoperative recurrence of NSCLC occurs, the prognosis is significantly poor, and the course of treatment after recurrence may influence overall survival (OS). Consequently, we investigated the relationship between relapse-free survival (RFS), post-progression survival (PPS), and OS in patients with postoperative recurrence of NSCLC with driver gene mutation/translocation negative or unknown status. METHODS: Between January 2007 and September 2019, 101 patients with driver gene mutation/translocation negative or unknown status of NSCLC who underwent complete resection and in whom recurrence occurred were analyzed. The associations between RFS, PPS, and OS were analyzed at the individual patient level. RESULTS: Linear regression and Spearman rank correlation analyses revealed that PPS was strongly associated with OS (r = 0.83, p < 0.0001, R2 = 0.71), whereas RFS was moderately correlated with OS (r = 0.65, p < 0.0001, R2 = 0.48). In the multivariate analysis, performance status at relapse, administration of immune checkpoint inhibitors, and radiotherapy for oligo-recurrences were significantly associated with PPS (p < 0.001). CONCLUSION: Current analysis of individual-level data of patients who underwent complete resection implied that PPS had a higher impact on OS than RFS in patients with postoperative recurrence of driver gene mutation/translocation negative or unknown status of NSCLC. Additionally, current perceptions indicate that treatment beyond progression after complete surgical resection might strongly affect OS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Oncology Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Oncology Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza