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Biocompatibility, antioxidant activity and collagen photoprotection properties of C60 fullerene adduct with L-methionine.
Sharoyko, Vladimir V; Shemchuk, Olga S; Meshcheriakov, Anatolii A; Vasina, Lubov V; Iamalova, Nailia R; Luttsev, Michail D; Ivanova, Daria A; Petrov, Andrey V; Maystrenko, Dmitriy N; Molchanov, Oleg E; Semenov, Konstantin N.
Afiliación
  • Sharoyko VV; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia; Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, Saint Petersburg, Russia. Electronic address: sharoyko@gmai
  • Shemchuk OS; Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia.
  • Meshcheriakov AA; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia; Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia.
  • Vasina LV; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia.
  • Iamalova NR; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia.
  • Luttsev MD; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia.
  • Ivanova DA; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia.
  • Petrov AV; Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia.
  • Maystrenko DN; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, Saint Petersburg, Russia.
  • Molchanov OE; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, Saint Petersburg, Russia.
  • Semenov KN; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia; Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, Saint Petersburg, Russia. Electronic address: knsemenov@gma
Nanomedicine ; 40: 102500, 2022 02.
Article en En | MEDLINE | ID: mdl-34843985
Functionalization of the fullerene core with amino acids has become a new and promising direction in the field of nanochemistry. The biologic activity of water-soluble fullerene derivatives is based on such properties as lipophilicity, electron deficiency and photosensitivity. The complex of above-mentioned properties can be used to develop protection of biomolecules (in particular, proteins) from external physical and chemical influences. Thus, development and up-scaling of synthesis procedures, as well as investigation of the biological properties of these derivatives, are extremely important. This paper presents new data on the biocompatibility studies of C60 fullerene adduct with L-methionine (C60[C5H11NO2S]3; C60-Met). Antiradical activity, binding to human serum albumin (HSA), collagen and deoxyribonucleic acid (DNA), hemocompatibility, photodynamic properties, genotoxicity and cytotoxicity were studied. In addition, it was found that C60-Met increases the photostability of the collagen molecule, and this effect is dose-dependent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fulerenos Límite: Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fulerenos Límite: Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos