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Glial Fibrillary Acidic Protein (GFAP) Astrocytopathy Presenting as Mild Encephalopathy with Reversible Splenium Lesion.
Héraud, Charlotte; Capet, Nicolas; Levraut, Michaël; Hattenberger, Robin; Bourg, Véronique; Thomas, Pierre; Mondot, Lydiane; Lebrun-Frenay, Christine.
Afiliación
  • Héraud C; Service de Neurologie, Centre Hospitalier Universitaire de Nice, 30 Voie Romaine, 06100, Nice, France. heraud.c@chu-nice.fr.
  • Capet N; Service de Neurologie, Centre Hospitalier Universitaire de Nice, 30 Voie Romaine, 06100, Nice, France.
  • Levraut M; Service de Neurologie, Centre Hospitalier Universitaire de Nice, URC2A-URRIS, Université de Nice Côte d'Azur, CRC SEP, 30 Voie Romaine, Nice, France.
  • Hattenberger R; Service de Neurologie, Centre Hospitalier Universitaire de Nice, URC2A-URRIS, Université de Nice Côte d'Azur, CRC SEP, 30 Voie Romaine, Nice, France.
  • Bourg V; Service de Médecine Interne, Centre Hospitalier Universitaire de Nice, 30 Voie Romaine, Nice, France.
  • Thomas P; Service de Neurologie, Centre Hospitalier Universitaire de Nice, 30 Voie Romaine, 06100, Nice, France.
  • Mondot L; Service de Neurologie, Centre Hospitalier Universitaire de Nice, 30 Voie Romaine, 06100, Nice, France.
  • Lebrun-Frenay C; Service de Neurologie, Centre Hospitalier Universitaire de Nice, 30 Voie Romaine, 06100, Nice, France.
Neurol Ther ; 11(1): 499-505, 2022 Mar.
Article en En | MEDLINE | ID: mdl-34843090
INTRODUCTION: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is scarce and usually presents as meningoencephalomyelitis. Here, we offer the case of an atypical presentation of GFAP-astrocytopathy. CASE PRESENTATION: We report the case of a 26-year-old woman admitted to our neurology department for a 3-week progressive and worsening neurologic picture, with secondary worsening. Initial imaging showed a Mild Encephalitis with Reversible Splenium of corpus callosum lesion (MERS). Full infectious and autoimmune workup then revealed positivity of GFAP antibodies, leading us to diagnose GFAP astrocytopathy. DISCUSSION: Our case is the first reported association between MERS and GFAP astrocytopathy in an adult patient. Clinical presentation of GFAP astrocytopathy usually includes various neurologic symptoms and can lead to misdiagnosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurol Ther Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurol Ther Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Nueva Zelanda