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Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking.
Guseva, Galina B; Antina, Elena V; Berezin, Mikhail B; Ksenofontov, Alexander A; Bocharov, Pavel S; Smirnova, Anastassia S; Pavelyev, Roman S; Gilfanov, Ilmir R; Pestova, Svetlana V; Izmest'ev, Evgeny S; Rubtsova, Svetlana A; Kayumov, Airat R; Kiselev, Sergei V; Azizova, Zulfiya R; Ostolopovskaya, Olga V; Efimov, Sergey V; Klochkov, Vladimir V; Khodov, Ilya A; Nikitina, Liliya E.
Afiliación
  • Guseva GB; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia. Electronic address: gbg@isc-ras.ru.
  • Antina EV; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.
  • Berezin MB; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.
  • Ksenofontov AA; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.
  • Bocharov PS; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia; Ivanovo State University of Chemistry and Technology, 7, Sheremetevskiy Avenue, 153000 Ivanovo, Russia.
  • Smirnova AS; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia; Ivanovo State University of Chemistry and Technology, 7, Sheremetevskiy Avenue, 153000 Ivanovo, Russia.
  • Pavelyev RS; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
  • Gilfanov IR; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
  • Pestova SV; Institute of Chemistry, Federal Research Center "Komi Scientific Centre", Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 48, 167000 Syktyvkar, Russia.
  • Izmest'ev ES; Institute of Chemistry, Federal Research Center "Komi Scientific Centre", Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 48, 167000 Syktyvkar, Russia.
  • Rubtsova SA; Institute of Chemistry, Federal Research Center "Komi Scientific Centre", Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 48, 167000 Syktyvkar, Russia.
  • Kayumov AR; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
  • Kiselev SV; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
  • Azizova ZR; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
  • Ostolopovskaya OV; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
  • Efimov SV; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
  • Klochkov VV; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
  • Khodov IA; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.
  • Nikitina LE; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.
Spectrochim Acta A Mol Biomol Spectrosc ; 268: 120638, 2022 Mar 05.
Article en En | MEDLINE | ID: mdl-34840052
This paper is devoted to the design of a fluorescent probe based on meso-carboxysubstituted-BODIPY with a thioterpene fragment. The functional replacement of the methoxy group in the BODIPY molecule on a thioterpene fragment was carried out in order to find out the antiplatelet and anticoagulant action mechanisms of thioterpenoids and to assess the membrane and receptor factors contributions. The molecular structure of the conjugate was confirmed via UV/vis-, NMR- and MS-spectra. It is found that the probe is a high fluorescence quantum yield (to âˆ¼ 100%) in the blue-green region at 509-516 nm. Molecular docking of all studied molecules showed that the BODIPY with terpenoid conjugation is an excellent way to increase their affinity to platelet receptor P2Y12.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Boro / Colorantes Fluorescentes Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Boro / Colorantes Fluorescentes Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido