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Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response.
He, Jiang; Liu, Liyu; Tang, Feiyu; Zhou, You; Liu, Huan; Lu, Can; Feng, Deyun; Zhu, Hong; Mao, Yitao; Li, Zhi; Zhang, Lu; Duan, Yuemei; Xiao, Zhi; Zeng, Musheng; Weng, Liang; Sun, Lun-Quan.
Afiliación
  • He J; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Liu L; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China.
  • Tang F; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Zhou Y; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China.
  • Liu H; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Lu C; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China.
  • Feng D; Department of Pathology, Tongji Medical College Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Zhu H; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Mao Y; Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, China.
  • Li Z; Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, China.
  • Zhang L; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Duan Y; Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410078, China.
  • Xiao Z; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Zeng M; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China.
  • Weng L; Institute of Gerontological Cancer Research, National Clinical Research Center for Gerontology, Changsha, 410008, China.
  • Sun LQ; Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
Signal Transduct Target Ther ; 6(1): 408, 2021 11 26.
Article en En | MEDLINE | ID: mdl-34836940
Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection is the risk factors for nasopharyngeal carcinoma and cervical carcinoma, respectively. However, clinical analyses demonstrate that EBV or HPV is associated with improved response of patients, although underlying mechanism remains unclear. Here, we reported that the oncoproteins of DNA viruses, such as LMP1 of EBV and E7 of HPV, inhibit PERK activity in cancer cells via the interaction of the viral oncoproteins with PERK through a conserved motif. Inhibition of PERK led to increased level of reactive oxygen species (ROS) that promoted tumor and enhanced the efficacy of chemotherapy in vivo. Consistently, disruption of viral oncoprotein-PERK interactions attenuated tumor growth and chemotherapy in both cancer cells and tumor-bearing mouse models. Our findings uncovered a paradoxical effect of DNA tumor virus oncoproteins on tumors and highlighted that targeting PERK might be an attractive strategy for the treatment of NPC and cervical carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papillomaviridae / Neoplasias del Cuello Uterino / Proteínas Oncogénicas Virales / Proteínas de la Matriz Viral / Neoplasias Nasofaríngeas / Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr / Infecciones por Papillomavirus / Carcinoma Nasofaríngeo / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Signal Transduct Target Ther Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papillomaviridae / Neoplasias del Cuello Uterino / Proteínas Oncogénicas Virales / Proteínas de la Matriz Viral / Neoplasias Nasofaríngeas / Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr / Infecciones por Papillomavirus / Carcinoma Nasofaríngeo / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Signal Transduct Target Ther Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido