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Circulating Structurally Related (-)-Epicatechin Metabolite Species and Levels after Sustained Intake of a Cocoa Powder High in Polyphenols Are Comparable to Those Achieved after a Single Dose.
Barrera-Reyes, Paloma K; Cortés-Fernández de Lara, Josué; Poquet, Laure; Redeuil, Karine; Kussmann, Martin; Silva-Zolezzi, Irma; Tejero, Elizabeth M.
Afiliación
  • Barrera-Reyes PK; Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
  • Cortés-Fernández de Lara J; Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
  • Poquet L; Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
  • Redeuil K; Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
  • Kussmann M; Nestlé Research Lausanne, Société des Produits Nestlé, 57 route du Jorat, CH-1000 Lausanne 25, Switzerland.
  • Silva-Zolezzi I; Nestlé Research Lausanne, Société des Produits Nestlé, 57 route du Jorat, CH-1000 Lausanne 25, Switzerland.
  • Tejero EM; Nuritas Limited, D02 RY95 Dublin, Ireland.
Nutrients ; 13(11)2021 Oct 27.
Article en En | MEDLINE | ID: mdl-34836088
BACKGROUND: While the bioavailability of cocoa polyphenols, particularly of the monomer (-)-epicatechin, has been investigated after a single-dose intake, the effect of sustained cocoa consumption on the metabolic profile of the structurally related (-)-epicatechin metabolites (SREMs) has not been investigated. METHODS: A randomized, controlled crossover clinical trial in healthy young adults (18-40 year) was conducted to evaluate SREMs after consumption of a single-dose and after daily consumption of 1.3 g of polyphenol-rich cocoa powder for 28 days. The circulating SREMs were measured by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). RESULTS: Twenty subjects (eleven males and nine females) were enrolled. The SREMs concentrations increased to 1741 ± 337 nM after a single-dose and to 1445 ± 270 nM after sustained supplementation. Sulfate conjugates showed higher levels in females (p < 0.05). The epicatechin-3'-glucuronide (E3'G) and epicatechin-3'-sulfate (E3'S) were the most abundant metabolites in all subjects. A high intra-individual correlation (r = 0.72, p < 0.001) between SREMs concentrations after single-dose and sustained supplementation was observed. The antioxidant capacity of plasma did not change in response to the intervention and was not correlated with any of the SREMs. CONCLUSION: The individual SREMs profile and concentrations after a 28-day supplementation are comparable to those after a single dose.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catequina / Suplementos Dietéticos / Ingestión de Alimentos / Polifenoles / Chocolate Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catequina / Suplementos Dietéticos / Ingestión de Alimentos / Polifenoles / Chocolate Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza