Your browser doesn't support javascript.
loading
Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice.
Shuster, Benjamin; Casserly, Ryan; Lipford, Erika; Olszewski, Rafal; Milon, Béatrice; Viechweg, Shaun; Davidson, Kanisa; Enoch, Jennifer; McMurray, Mark; Rutherford, Mark A; Ohlemiller, Kevin K; Hoa, Michael; Depireux, Didier A; Mong, Jessica A; Hertzano, Ronna.
Afiliación
  • Shuster B; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Casserly R; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Lipford E; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Olszewski R; Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
  • Milon B; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Viechweg S; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Davidson K; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Enoch J; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • McMurray M; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Rutherford MA; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Ohlemiller KK; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Hoa M; Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
  • Depireux DA; Otolith Labs, Washington, DC 20036, USA.
  • Mong JA; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Hertzano R; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Int J Mol Sci ; 22(22)2021 Nov 11.
Article en En | MEDLINE | ID: mdl-34830090
Recent studies have identified sex-differences in auditory physiology and in the susceptibility to noise-induced hearing loss (NIHL). We hypothesize that 17ß-estradiol (E2), a known modulator of auditory physiology, may underpin sex-differences in the response to noise trauma. Here, we gonadectomized B6CBAF1/J mice and used a combination of electrophysiological and histological techniques to study the effects of estrogen replacement on peripheral auditory physiology in the absence of noise exposure and on protection from NIHL. Functional analysis of auditory physiology in gonadectomized female mice revealed that E2-treatment modulated the peripheral response to sound in the absence of changes to the endocochlear potential compared to vehicle-treatment. E2-replacement in gonadectomized female mice protected against hearing loss following permanent threshold shift (PTS)- and temporary threshold shift (TTS)-inducing noise exposures. Histological analysis of the cochlear tissue revealed that E2-replacement mitigated outer hair cell loss and cochlear synaptopathy following noise exposure compared to vehicle-treatment. Lastly, using fluorescent in situ hybridization, we demonstrate co-localization of estrogen receptor-2 with type-1C, high threshold spiral ganglion neurons, suggesting that the observed protection from cochlear synaptopathy may occur through E2-mediated preservation of these neurons. Taken together, these data indicate the estrogen signaling pathways may be harnessed for the prevention and treatment of NIHL.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cóclea / Estradiol / Potenciales Evocados Auditivos / Pérdida Auditiva Provocada por Ruido Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cóclea / Estradiol / Potenciales Evocados Auditivos / Pérdida Auditiva Provocada por Ruido Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza