Rodent Brain Pathology, Audiogenic Epilepsy.

Fedotova, Irina B; Surina, Natalia M; Nikolaev, Georgy M; Revishchin, Alexandre V; Poletaeva, Inga I

Fedotova, Irina B; Surina, Natalia M; Nikolaev, Georgy M; Revishchin, Alexandre V; Poletaeva, Inga I.

Afiliación

Fedotova IB; Department of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Surina NM; Department of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Nikolaev GM; Department of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Revishchin AV; Institute for Higher Nervous Activity, RAS, 119234 Moscow, Russia.
Poletaeva II; Department of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.

Biomedicines ; 9(11)2021 Nov 08.

Article en En | MEDLINE | ID: mdl-34829870

RESUMEN

The review presents data which provides evidence for the internal relationship between the stages of rodent audiogenic seizures and post-ictal catalepsy with the general pattern of animal reaction to the dangerous stimuli and/or situation. The wild run stage of audiogenic seizure fit could be regarded as an intense panic reaction, and this view found support in numerous experimental data. The phenomenon of audiogenic epilepsy probably attracted the attention of physiologists as rodents are extremely sensitive to dangerous sound stimuli. The seizure proneness in this group shares common physiological characteristics and depends on animal genotype. This concept could be the new platform for the study of epileptogenesis mechanisms.

Palabras clave

audiogenic epilepsy; behavior genetics; fear reaction; rodents

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomedicines Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza

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