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The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach.
Ríos-Tamayo, Rafael; Puig, Noemí; Algarín, Macarena; García de Veas Silva, José Luís; Barbosa, Nuno; Encinas, Cristina; Hernández, José Ángel; Alonso, Rafael; Campos, María Luisa; Rodríguez, Teresa; Leivas, Alberto; Olivares, María José; Sánchez, María José; Paiva, Bruno; Lahuerta, Juan José; Martínez-López, Joaquín.
Afiliación
  • Ríos-Tamayo R; Hematology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
  • Puig N; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), 18014 Granada, Spain.
  • Algarín M; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
  • García de Veas Silva JL; Hematology Department, Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC) CIBERONC, 37007 Salamanca, Spain.
  • Barbosa N; Scientific Department, The Binding Site Iberia, 08038 Barcelona, Spain.
  • Encinas C; Molecular Diagnosis Laboratory Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
  • Hernández JÁ; Scientific Department, The Binding Site Iberia, 08038 Barcelona, Spain.
  • Alonso R; Hematology Department, Hospital General Universitario Gregorio Marañón, IiGM, 28009 Madrid, Spain.
  • Campos ML; Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.
  • Rodríguez T; Hematology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
  • Leivas A; Scientific Department, The Binding Site Iberia, 08038 Barcelona, Spain.
  • Olivares MJ; Immunology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
  • Sánchez MJ; Scientific Department, The Binding Site Iberia, 08038 Barcelona, Spain.
  • Paiva B; Immunology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
  • Lahuerta JJ; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), 18014 Granada, Spain.
  • Martínez-López J; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
Diagnostics (Basel) ; 11(11)2021 Oct 30.
Article en En | MEDLINE | ID: mdl-34829367
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Diagnostics (Basel) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza