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In situ-formed adhesive hyaluronic acid hydrogel with prolonged amnion-derived conditioned medium release for diabetic wound repair.
Zhang, Yiqing; Zheng, Yongjun; Shu, Futing; Zhou, Renjie; Bao, Bingkun; Xiao, Shichu; Li, Kai; Lin, Qiuning; Zhu, Linyong; Xia, Zhaofan.
Afiliación
  • Zhang Y; School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
  • Zheng Y; School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China; Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address: smmuzhengyongjun@163.com.
  • Shu F; Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
  • Zhou R; School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
  • Bao B; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Xiao S; Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
  • Li K; School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
  • Lin Q; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
  • Zhu L; School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: linyongzhu@ecust.edu.cn.
  • Xia Z; Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address: xiazhaofan_smmu@163.com.
Carbohydr Polym ; 276: 118752, 2022 Jan 15.
Article en En | MEDLINE | ID: mdl-34823781
Hydrogels have long been used for encapsulating stem cell-derived conditioned mediums to achieve skin regeneration after wounding. However, inappropriate mechanical strength, low adhesion and low elasticity limit their clinical application. To address these challenges, we engineered a hyaluronic acid-based hydrogel grafted with methacrylic anhydride and N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butanamide (NB) groups to encapsulate a lyophilized amnion-derived conditioned medium (AM-CM). This hydrogel can photopolymerize in situ within 3 s by photo-initiated free-radical crosslinking between methacrylate moieties. Meanwhile, the formed o-nitrosobenzaldehyde groups by photo-irradiation could covalently bond with the amino groups of tissue surface, which allowed strong tissue adhesion. Furthermore, the hydrogel possessed excellent mechanical properties, high elasticity, favorable biocompatibility and prolonged AM-CM release. Our further vitro and in vivo studies showed that the hydrogel significantly accelerated diabetic wound healing by regulating macrophage polarization and promoting angiogenesis. The engineered hydrogel with AM-CM release has high potential to treat chronic wounds in clinics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Hidrogeles / Diabetes Mellitus / Amnios / Ácido Hialurónico Límite: Animals / Humans / Male Idioma: En Revista: Carbohydr Polym Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Hidrogeles / Diabetes Mellitus / Amnios / Ácido Hialurónico Límite: Animals / Humans / Male Idioma: En Revista: Carbohydr Polym Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido