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Probing the Therapeutic Potential of Marine Phyla by SPE Extraction.
Moreiras-Figueruelo, Alejandro; Nuzzo, Genoveffa; Galasso, Christian; Sansone, Clementina; Crocetta, Fabio; Mazzella, Valerio; Gallo, Carmela; Barra, Giusi; Sardo, Angela; Iuliano, Antonella; Manzo, Emiliano; d'Ippolito, Giuliana; Albrigtsen, Marte; Andersen, Jeanette H; Ianora, Adrianna; Fontana, Angelo.
Afiliación
  • Moreiras-Figueruelo A; Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy.
  • Nuzzo G; Consorzio Italbiotec, Via Gaudenzio Fantoli, 16/15, 20138 Milano, Italy.
  • Galasso C; Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy.
  • Sansone C; Calabrian Researches Centre and Marine Advanced Infrastructures, Department of Marine Biotechnology, National Institute of Biology, Ecology and Marine Biotechnology, Stazione Zoologica Anton Dohrn, C.da Torre Spaccata, 87071 Amendolara, Italy.
  • Crocetta F; Departmentt of Marine Biotechnology, National Institute of Biology, Ecology and Marine Biotechnology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy.
  • Mazzella V; Department of Integrative Marine Ecology, National Institute of Biology, Ecology and Marine Biotechnology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy.
  • Gallo C; Department of Integrative Marine Ecology, National Institute of Biology, Ecology and Marine Biotechnology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy.
  • Barra G; Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy.
  • Sardo A; Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy.
  • Iuliano A; Departmentt of Marine Biotechnology, National Institute of Biology, Ecology and Marine Biotechnology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy.
  • Manzo E; Department of Mathematics, Computer Science and Economics, Campus Macchia Romana, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
  • d'Ippolito G; Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy.
  • Albrigtsen M; Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy.
  • Andersen JH; The Norwegian College of Fishery Science, Marbio, UiT-The Arctic University of Norway, 9019 Tromsø, Norway.
  • Ianora A; The Norwegian College of Fishery Science, Marbio, UiT-The Arctic University of Norway, 9019 Tromsø, Norway.
  • Fontana A; Departmentt of Marine Biotechnology, National Institute of Biology, Ecology and Marine Biotechnology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy.
Mar Drugs ; 19(11)2021 Nov 16.
Article en En | MEDLINE | ID: mdl-34822511
The marine environment is potentially a prolific source of small molecules with significant biological activities. In recent years, the development of new chromatographic phases and the progress in cell and molecular techniques have facilitated the search for marine natural products (MNPs) as novel pharmacophores and enhanced the success rate in the selection of new potential drug candidates. However, most of this exploration has so far been driven by anticancer research and has been limited to a reduced number of taxonomic groups. In this article, we report a test study on the screening potential of an in-house library of natural small molecules composed of 285 samples derived from 57 marine organisms that were chosen from among the major eukaryotic phyla so far represented in studies on bioactive MNPs. Both the extracts and SPE fractions of these organisms were simultaneously submitted to three different bioassays-two phenotypic and one enzymatic-for cytotoxic, antidiabetic, and antibacterial activity. On the whole, the screening of the MNP library selected 11 potential hits, but the distribution of the biological results showed that SPE fractionation increased the positive score regardless of the taxonomic group. In many cases, activity could be detected only in the enriched fractions after the elimination of the bulky effect due to salts. On a statistical basis, sponges and molluscs were confirmed to be the most significant source of cytotoxic and antimicrobial products, but other phyla were found to be effective with the other therapeutic targets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organismos Acuáticos / Antineoplásicos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organismos Acuáticos / Antineoplásicos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza