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Cytotoxic Indole-Diterpenoids from the Marine-Derived Fungus Penicillium sp. KFD28.
Dai, Lu-Ting; Yang, Li; Kong, Fan-Dong; Ma, Qing-Yun; Xie, Qing-Yi; Dai, Hao-Fu; Yu, Zhi-Fang; Zhao, You-Xing.
Afiliación
  • Dai LT; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
  • Yang L; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Kong FD; Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineer
  • Ma QY; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Xie QY; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Dai HF; Hainan Institute for Tropical Agricultural Resources, CATAS, Haikou 571101, China.
  • Yu ZF; College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
  • Zhao YX; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
Mar Drugs ; 19(11)2021 Oct 28.
Article en En | MEDLINE | ID: mdl-34822484
Four new indole-diterpenoids, named penerpenes K-N (1-4), along with twelve known ones (5-16), were isolated from the fermentation broth produced by adding L-tryptophan to the culture medium of the marine-derived fungus Penicillium sp. KFD28. The structures of the new compounds were elucidated extensively by 1D and 2D NMR, HRESIMS data spectroscopic analyses and ECD calculations. Compound 4 represents the second example of paxilline-type indole diterpene bearing a 1,3-dioxepane ring. Three compounds (4, 9, and 15) were cytotoxic to cancer cell lines, of which compound 9 was the most active and showed cytotoxic activity against the human liver cancer cell line BeL-7402 with an IC50 value of 5.3 µM. Moreover, six compounds (5, 7, 10, 12, 14, and 15) showed antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicillium / Diterpenos / Indoles / Antibacterianos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicillium / Diterpenos / Indoles / Antibacterianos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza