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Comparative study of royal jelly, propolis, and photobiomodulation therapies in 5-fluorouracil-related oral mucositis in rats.
Severo, Mara Luana Batista; Thieme, Stéfanie; Silveira, Felipe Martins; Tavares, Raquel Padilha Martins; Gonzaga, Amanda Katarinny Goes; Zucolotto, Silvana Maria; de Araújo, Aurigena Antunes; Martins, Marco Antonio Trevizani; Martins, Manoela Domingues; da Silveira, Éricka Janine Dantas.
Afiliación
  • Severo MLB; Dentistry Department, Postgraduate Program in Dental Sciences, Federal University of Rio Grande Norte, Av. Senador Salgado Filho, Lagoa Nova, Natal, RN, 1787, Brazil.
  • Thieme S; Department of Oral Pathology, Dental School, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Silveira FM; Department of Oral Pathology, Dental School, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Tavares RPM; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
  • Gonzaga AKG; Department of Pharmacy, School of Pharmacy, Federal University of Rio Grande Norte, Natal, Brazil.
  • Zucolotto SM; Department of Dentistry, UNIFACISA University Center, Campina Grande, PB, Brazil.
  • de Araújo AA; Department of Pharmacy, School of Pharmacy, Federal University of Rio Grande Norte, Natal, Brazil.
  • Martins MAT; Dentistry Department, Postgraduate Program in Dental Sciences, Federal University of Rio Grande Norte, Av. Senador Salgado Filho, Lagoa Nova, Natal, RN, 1787, Brazil.
  • Martins MD; Department of Oral Pathology, Dental School, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • da Silveira ÉJD; Department of Oral Pathology, Dental School, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Support Care Cancer ; 30(3): 2723-2734, 2022 Mar.
Article en En | MEDLINE | ID: mdl-34822003
PURPOSE: This study aimed to evaluate the effects and mechanisms of action of royal jelly (RJ) and propolis compared to photobiomodulation therapy (PBMT) in an animal model of 5-fluorouracil-related oral mucositis (OM). METHODS: Seventy-two male Wistar rats were randomly allocated to four groups (n = 18 each): control (no treatment), PBMT (intraoral laser, 6 J/cm2), RJ, and propolis. On days 0 and 2, the animals received an injection of 5-fluorouracil (5-FU). The buccal mucosa was scratched (days 3 and 4) and the treatments were initiated on day 5. Six animals of each group were euthanized on days 8, 10, and 14. Phytochemical analysis (thin-layer chromatography, TLC) and clinical, histopathological, and immunohistochemical analysis of pS6, pAKT, and NF-κB were performed, and oxidative stress markers were also investigated. RESULTS: TLC revealed the presence of large amounts of sucrose (Rf 0.34) in RJ and of flavonoids in propolis. Lower clinical OM scores were observed on day 8, and improved morphological data were observed on day 10 in the PBMT, RJ, and propolis groups (p < 0.05). On day 8, immunoexpression of pS6, pAKT, and NF-κB was increased compared to control. On day 14, reduced glutathione (GSH) antioxidant levels were increased in the propolis group compared to control (p < 0.05). CONCLUSIONS: Our results showed that RJ and propolis, as well as PBMT, are effective in the treatment of OM. Considering that some patients who develop OM do not have access to PBMT, the present study demonstrated that topical application of RJ and propolis may be an important alternative for the treatment of OM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Própolis / Estomatitis / Terapia por Luz de Baja Intensidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Própolis / Estomatitis / Terapia por Luz de Baja Intensidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania