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Association between baseline insulin resistance and psoriasis incidence: the Women's Health Initiative.
Chan, Alfred A; Li, Houmin; Li, Wendy; Pan, Kathy; Yee, Jennifer K; Chlebowski, Rowan T; Lee, Delphine J.
Afiliación
  • Chan AA; Division of Dermatology, The Lundquist Institute, 1124 West Carson Street, Torrance, CA, 90503, USA.
  • Li H; Division of Dermatology, Peking University People's Hospital, Xicheng District, Beijing, China.
  • Li W; Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Pan K; Division of Medical Oncology and Hematology, The Lundquist Institute, Torrance, CA, USA.
  • Yee JK; Division of Pediatric Endocrinology, The Lundquist Institute, Torrance, CA, USA.
  • Chlebowski RT; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Lee DJ; Division of Medical Oncology and Hematology, The Lundquist Institute, Torrance, CA, USA.
Arch Dermatol Res ; 314(9): 869-880, 2022 Nov.
Article en En | MEDLINE | ID: mdl-34816303
Small-scale studies offer conflicting evidence regarding the relationship/association between psoriasis and insulin resistance by HOMA-IR (homeostasis model assessment of insulin resistance). The purpose of this study was to assess the association between baseline HOMA-IR and psoriasis incidence in a large-scale longitudinal cohort of postmenopausal women. The analysis included 21,789 postmenopausal women from the Women's Health Initiative. Psoriasis diagnosis was defined by fee-for-service Medicare ICD-9-CM codes assigned by dermatologists or rheumatologists, and a 2-year lookback period to exclude prevalent cases. Baseline HOMA-IR was calculated using the updated HOMA2 model. Hazard rates from the Cox regression models were stratified by age (10-year intervals), on WHI component (Clinical Trial or Observational Study), and on randomization status within each of the WHI clinical trials. The complete model also adjusted for ethnicity, waist-hip-ratio, and smoking and alcohol habits. Among participants free of psoriasis at entry, those with high baseline HOMA-IR (≥ 2) compared to low (< 1.4) had significantly higher risk for psoriasis over 21-year cumulative follow-up (HR: 1.39, 95% CI 1.08-1.79, P-trend: 0.011). In postmenopausal women, higher baseline HOMA-IR levels were significantly associated with higher incidence of psoriasis over 21-year cumulative follow-up. Results from this time-to-event analysis indicate that insulin resistance can precede and is associated with an increased risk of psoriasis. Study is limited by Medicare diagnostic code accuracy and cohort age.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Resistencia a la Insulina Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans País/Región como asunto: America do norte Idioma: En Revista: Arch Dermatol Res Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Resistencia a la Insulina Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans País/Región como asunto: America do norte Idioma: En Revista: Arch Dermatol Res Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania