Your browser doesn't support javascript.
loading
Temporal Patterns of Spontaneous Fixational Eye Movements: The Influence of Basal Ganglia.
Beylergil, Sinem Balta; Murray, Jordan; Noecker, Angela M; Gupta, Palak; Kilbane, Camilla; McIntyre, Cameron C; Ghasia, Fatema F; Shaikh, Aasef G.
Afiliación
  • Beylergil SB; Department of Biomedical Engineering (SBB, AMN, PG, CCM, AGS), Case Western Reserve University, Cleveland, Ohio; National VA Parkinson Consortium Center (PG, AGS), Neurology Service, Daroff-Dell'Osso Ocular Motility and Vestibular Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio; Cole Eye Institute (JM), Cleveland Clinic, Cleveland, Ohio; Department of Neurology (CK, AGS), Case Western Reserve University, Cleveland, Ohio; and Movement Disorders Center (CK, AGS), Neurological
J Neuroophthalmol ; 42(1): 45-55, 2022 03 01.
Article en En | MEDLINE | ID: mdl-34812763
BACKGROUND: Spontaneity is a unique feature of the nervous system. One of the fundamentally critical and recognized forms of spontaneous motor activity is witnessed in the visuomotor system. Microsaccades, the miniature spontaneous eye movements, are critical for the visual perception. We hypothesized that microsaccades follow specific temporal patterns that are modulated by the basal ganglia output. METHODS: We used high-resolution video-oculography to capture microsaccades in 48 subjects (31 healthy and 17 with Parkinson's disease) when subjects were asked to hold their gaze on a straight-ahead target projected on white background. We analyzed spontaneous discharge patterns of microsaccades. RESULTS: The first analysis considering coefficient of variation in intersaccadic interval distribution demonstrated that microsaccades in Parkinson's disease are more dispersed than the control group. The second analysis scrutinized microsaccades' temporal variability and revealed 3 distinct occurrence patterns: regular rhythmic, clustered, and randomly occurring following a Poisson-like process. The regular pattern was relatively more common in Parkinson's disease. Subthalamic DBS modulated this temporal pattern. The amount of change in the temporal variability depended on the DBS-induced volume of tissue activation and its overlap with the subthalamic nucleus. The third analysis determined the autocorrelations of microsaccades within 2-second time windows. We found that Parkinson's disease altered local temporal organization in microsaccade generation, and DBS had a modulatory effect. CONCLUSION: The microsaccades occur in 3 temporal patterns. The basal ganglia are one of the modulators of the microsaccade spontaneity.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Movimientos Sacádicos Límite: Humans Idioma: En Revista: J Neuroophthalmol Asunto de la revista: NEUROLOGIA / OFTALMOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Movimientos Sacádicos Límite: Humans Idioma: En Revista: J Neuroophthalmol Asunto de la revista: NEUROLOGIA / OFTALMOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos