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Derivatizing merocyanine dyes to balance their polarity and viscosity sensitivities for protein aggregation detection.
Bai, Yulong; Huang, Yanan; Wan, Wang; Jin, Wenhan; Shen, Di; Lyu, Haochen; Zeng, Lianggang; Liu, Yu.
Afiliación
  • Bai Y; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
  • Huang Y; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Wan W; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
  • Jin W; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
  • Shen D; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
  • Lyu H; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
  • Zeng L; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
  • Liu Y; CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. liuyu@dicp.ac.cn.
Chem Commun (Camb) ; 57(98): 13313-13316, 2021 Dec 09.
Article en En | MEDLINE | ID: mdl-34812440
Protein misfolding and aggregation processes involve local polarity and viscosity fluctuation. Herein we modulated the polarity and viscosity sensitivities of merocyanine dyes to detect protein aggregation. We demonstrated how structural modulation balanced these two fluorescence sensitivities and affected the detection of misfolded and aggregated proteins.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzopiranos / Deficiencias en la Proteostasis / Agregación Patológica de Proteínas / Indoles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzopiranos / Deficiencias en la Proteostasis / Agregación Patológica de Proteínas / Indoles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido