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Dysglycemia and incident heart failure among blacks: The jackson heart study.
Echouffo-Tcheugui, Justin B; Mwasongwe, Stanford E; Musani, Solomon K; Hall, Michael E; Correa, Adolfo; Hernandez, Adrian F; Golden, Sherita H; Mentz, Robert J; Bertoni, Alain G.
Afiliación
  • Echouffo-Tcheugui JB; Department of Medicine, Division Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD; Jackson State University, Jackson, MS. Electronic address: jechouf1@jhmi.edu.
  • Mwasongwe SE; Jackson State University, Jackson, MS.
  • Musani SK; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
  • Hall ME; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
  • Correa A; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
  • Hernandez AF; Department of Medicine, Duke University School of Medicine, Durham, NC.
  • Golden SH; Department of Medicine, Division Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD.
  • Mentz RJ; Department of Medicine, Duke University School of Medicine, Durham, NC.
  • Bertoni AG; Department of Epidemiology & Prevention, Wake Forest University School of Medicine, Winston-Salem, NC.
Am Heart J ; 245: 1-9, 2022 03.
Article en En | MEDLINE | ID: mdl-34808103
BACKGROUND: We aimed to investigate the associations of glycemic markers (hemoglobin A1C [HbA1C], fasting plasma glucose [FPG] and glycemic status [normoglycemia, prediabetes and diabetes]) with incident heart failure (HF) and its subtypes, among Blacks. METHODS: We included 2,290 community-dwelling Blacks (64% women, mean age 58 years) without prevalent HF from the Jackson Heart Study who attended the second exam (2005 - 2008). The associations between glycemic markers and incident HF (and subtypes including HF with preserved ejection fraction [HFpEF] and reduced ejection fraction [HFrEF]) were evaluated using Cox proportional hazards regression models, adjusting for risk factors and coronary heart disease. RESULTS: There were 119 incident HF events (48 HFpEF, 58 HFrEF, and 13 unclassified HF events) over a median follow-up of 10.5 years. Higher levels of HbA1C (HR per SD increment, 1.30; 95% CI 1.12, 1.51) and FPG (HR per SD increment FPG: 1.32; 95% CI: 1.17, 1.48) were associated with a higher risk of incident HF. Compared to normal glycemia, diabetes status was associated with a higher risk of incident HF (HR: 1.24; 95%CI: 1.02, 2.05). HbA1C was significantly associated with higher risks of HFpEF (HR per SD increment: 1.41, 95% CI: 1.18, 1.69) and HFrEF (HR per SD increment: 1.32; 95% CI: 1.12, 1.56). FPG was significantly associated with higher risk of HFpEF (HR per SD increment: 1.35, 95% CI: 1.14, 1.62) but not HFrEF (HR per SD increment: 1.12; 95% CI: 0.53, 2.35). CONCLUSIONS: Among community-dwelling Blacks, higher levels of glycemic markers were associated with higher risk of HF subtypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Am Heart J Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Am Heart J Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos