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Outcome of acute ischaemic stroke patients after intravenous alteplase in Hospital Universiti Sains Malaysia.
Wong, K Y; Baharuddin, K A; Masykurin, M M; Abdul Halim, S; Chee, Y C; Sapiai, N A; Abdullah, M S.
Afiliación
  • Wong KY; Universiti Sains Malaysia, School of Medical Sciences, Department of Emergency Medicine, Kubang Kerian, Kelantan, Malaysia.
  • Baharuddin KA; Universiti Sains Malaysia, School of Medical Sciences, Department of Emergency Medicine, Kubang Kerian, Kelantan, Malaysia. amararyff@usm.my.
  • Masykurin MM; Universiti Sains Malaysia, School of Medical Sciences, Department of Emergency Medicine, Kubang Kerian, Kelantan, Malaysia.
  • Abdul Halim S; Universiti Sains Malaysia, School of Medical Sciences, Department of Internal Medicine (Neurology), Kubang Kerian, Kelantan, Malaysia.
  • Chee YC; Universiti Sains Malaysia, School of Medical Sciences, Department of Internal Medicine (Neurology), Kubang Kerian, Kelantan, Malaysia.
  • Sapiai NA; Universiti Sains Malaysia, School of Medical Sciences, Department of Radiology, Kubang Kerian, Kelantan, Malaysia.
  • Abdullah MS; Universiti Sains Malaysia, School of Medical Sciences, Department of Radiology, Kubang Kerian, Kelantan, Malaysia.
Med J Malaysia ; 76(6): 870-875, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34806675
INTRODUCTION: Intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (rt-PA) is effective in treating acute ischaemic stroke. Our primary objective is to assess the outcome of these acute ischaemic stroke (AIS) patients after IV alteplase with the modified Rankin scale (mRS). METHODS: This is a cross-sectional study in which patients receiving IV alteplase in Hospital Universiti Sains Malaysia, from January 2017 to April 2020 were recruited. Demographical data, National Institutes of Health Stroke Scale (NIHSS) scores, door-to-needle time were recorded. Modified Rankin scale (mRS) scores were evaluated at 90 days after initial therapy. Good and poor functional outcomes were defined as 0-2 and 3-6, respectively. RESULTS: A total of 30 patients were included in the study with a mean age of 59±11.47 years old. 76.7% of them were male and the rest were female. From the study, onset-toneedle time was 197.47±51.74 minutes, whereas door-toneedle time was 120.93±53.63 minutes. Seventeen (56.3%) patients achieved a favourable score of 0-2 on the mRS at 90 days after treatment. Haemorrhagic transformation occurred in eight (26.7%) of the patients with a mortality rate of 13.3%. CONCLUSION: 56.7% of our patients showed improvement in the mRS at 90 days post thrombolysis for AIS. Higher baseline NIHSS scores and diabetes mellitus were associated with poorer functional outcomes after thrombolysis.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isquemia Encefálica / Activador de Tejido Plasminógeno / Accidente Cerebrovascular Isquémico Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Med J Malaysia Año: 2021 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Malasia
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isquemia Encefálica / Activador de Tejido Plasminógeno / Accidente Cerebrovascular Isquémico Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Med J Malaysia Año: 2021 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Malasia