Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis <i>in vivo</i>.

Feng, Fan; Pan, Lianhong; Wu, Jiaqin; Li, Lanqing; Xu, Haiying; Yang, Li; Xu, Kang; Wang, Chunli

Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo.

Feng, Fan; Pan, Lianhong; Wu, Jiaqin; Li, Lanqing; Xu, Haiying; Yang, Li; Xu, Kang; Wang, Chunli.

Afiliación

Feng F; National Innovation and Attracting Talents "111" base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Pan L; National Innovation and Attracting Talents "111" base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Wu J; Chongqing Engineering Research Center of Antitumor Natural Drugs, Chongqing Three Gorges Medical College, Chongqing 400030, China.
Li L; National Innovation and Attracting Talents "111" base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Xu H; Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
Yang L; Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
Xu K; National Innovation and Attracting Talents "111" base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Wang C; Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.

Int J Biol Sci ; 17(15): 4340-4352, 2021.

Article en En | MEDLINE | ID: mdl-34803502

Asunto(s)

Aminoácidos/metabolismo; Bencilisoquinolinas/farmacología; Carcinogénesis/efectos de los fármacos; Carcinoma Hepatocelular/tratamiento farmacológico; Proliferación Celular/efectos de los fármacos; Neoplasias Hepáticas/tratamiento farmacológico; Animales; Apoptosis/efectos de los fármacos; Bencilisoquinolinas/administración & dosificación; Bencilisoquinolinas/química; Caspasa 3/genética; Caspasa 3/metabolismo; Caspasa 9/genética; Caspasa 9/metabolismo; Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Supervivencia Celular; Relación Dosis-Respuesta a Droga; Femenino; Humanos; Ratones; Ratones Desnudos; Estructura Molecular; Neoplasias Experimentales; Distribución Aleatoria

Palabras clave

Apoptosis.; Cepharanthine; Hepatocellular carcinoma; Metabolism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Bencilisoquinolinas / Proliferación Celular / Carcinogénesis / Aminoácidos / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia

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