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30 day predicted outcome in undifferentiated chest pain: multicenter validation of the HEART score in Tunisian population.
Khalil, Mohamed Hassene; Sekma, Adel; Yaakoubi, Hajer; Bel Haj Ali, Khaoula; Msolli, Mohamed Amine; Beltaief, Kaouthar; Grissa, Mohamed Habib; Boubaker, Hamdi; Sassi, Mohamed; Chouchene, Hamadi; Hassen, Youssef; Ben Soltane, Houda; Mezgar, Zied; Boukef, Riadh; Bouida, Wahid; Nouira, Semir.
Afiliación
  • Khalil MH; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia. m.hassene.khalil@gmail.com.
  • Sekma A; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia. m.hassene.khalil@gmail.com.
  • Yaakoubi H; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia.
  • Bel Haj Ali K; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
  • Msolli MA; Emergency Department, Sahloul University Hospital, 4011, Sousse, Tunisia.
  • Beltaief K; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
  • Grissa MH; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia.
  • Boubaker H; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
  • Sassi M; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia.
  • Chouchene H; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
  • Hassen Y; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia.
  • Ben Soltane H; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
  • Mezgar Z; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia.
  • Boukef R; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
  • Bouida W; Emergency Department and Laboratory Research (LR12SP18), Fattouma Bourguiba University Hospital, 5000, Monastir, Tunisia.
  • Nouira S; Research Laboratory LR12SP18, University of Monastir, 5019, Monastir, Tunisia.
BMC Cardiovasc Disord ; 21(1): 555, 2021 11 19.
Article en En | MEDLINE | ID: mdl-34798811
BACKGROUND: Chest pain remains one of the most challenging serious complaints in the emergency department (ED). A prompt and accurate risk stratification tool for chest pain patients is paramount to help physcian effectively progrnosticate outcomes. HEART score is considered one of the best scores for chest pain risk stratification. However, most validation studies of HEART score were not performed in populations different from those included in the original one. OBJECTIVE: To validate HEART score as a prognostication tool, among Tunisian ED patients with undifferentiated chest pain. METHODS: Our prospective, multicenter study enrolled adult patients presenting with chest pain at chest pain units. Patients over 30 years of age with a primary complaint of chest pain were enrolled. HEART score was calculated for every patient. The primary outcome was major cardiovascular events (MACE) occurrence, including all-cause mortality, non-fatal myocardial infarction (MI), and coronary revascularisation over 30 days following the ED visit. The discriminative power of HEART score was evaluated by the area under the ROC curve. A calibration analysis of the HEART score in this population was performed using Hosmer-Lemeshow goodness of test. RESULTS: We enrolled 3880 patients (age 56.3; 59.5% males). The application of HEART score showed that most patients were in intermediate risk category (55.3%). Within 30 days of ED visit, MACE were reported in 628 (16.2%) patients, with an incidence of 1.2% in the low risk group, 10.8% in the intermediate risk group and 62.4% in the high risk group. The area under receiver operating characteristic curve was 0.87 (95% CI 0.85-0.88). HEART score was not well calibrated (χ2 statistic = 12.34; p = 0.03). CONCLUSION: HEART score showed a good discrimination performance in predicting MACE occurrence at 30 days for Tunisian patients with undifferentiated acute chest pain. Heart score was not well calibrated in our population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Apoyo para la Decisión / Isquemia Miocárdica / Angina de Pecho Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Apoyo para la Decisión / Isquemia Miocárdica / Angina de Pecho Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido