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Nanodesigning of multifunctional quantum dots and nanoparticles for the treatment of fibrosarcoma.
Demirbolat, Gulen Melike; Altintas, Levent; Yilmaz, Sukran; Arsoy, Taibe; Sözmen, Mahmut; Degim, Ismail Tuncer.
Afiliación
  • Demirbolat GM; Department of Pharmaceutical Technology, Biruni University Faculty of Pharmacy, Turkey, Istanbul.
  • Altintas L; Department of Pharmaceutical Technology, Gazi University Faculty of Pharmacy, Ankara, Turkey.
  • Yilmaz S; Department of Pharmacology and Toxicology, Ankara University Faculty of Veterinary Medicine, Ankara, Turkey.
  • Arsoy T; Food and Mouth Diseases Institute, Ankara, Turkey.
  • Sözmen M; Food and Mouth Diseases Institute, Ankara, Turkey.
  • Degim IT; Department of Preclinical Sciences, Ondokuz Mayis University Faculty of Veterinary, Samsun, Turkey.
J Microencapsul ; 39(3): 210-225, 2022 May.
Article en En | MEDLINE | ID: mdl-34796787
An effective, dual drug(DD) loaded nanocarrier system (nano particle(NP), quantum dots(QDs)) having two active substances was aimed to develop for the treatment of fibrosarcoma. Zinc oxide(ZnO) QDs were produced using zinc acetate dehydrate as a precursor, were incorporated with chitosan(Ch), and finally decorated with PEG-linked folic acid and were found to be effective after imatinib mesylate(IM) and dexketoprofen trometamol(DT) were loaded. Characterisations, in vitro drug releases, cell toxicities, penetrations through cell lines and in-vivo animal tests of the prepared nanosystems were performed. The size of hybrid nanoparticles were 168.6 ± 48.8 nm, surface charge was -35.8 ± 0.26 mV. The encapsulation efficiency was 75% for IM and 99% for DT. DD-functionalised QDChNPs and lyophilised functionalised QDChNPs in capsules slowed down tumour growth by up to 76.5 and 88.7%. Our results demonstrate that developed hybrid nanoparticles are highly effective. This hybrid system gathers many of the advantages of nanotechnology into one form.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Puntos Cuánticos / Quitosano / Nanopartículas / Fibrosarcoma Límite: Animals Idioma: En Revista: J Microencapsul Asunto de la revista: FARMACIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Puntos Cuánticos / Quitosano / Nanopartículas / Fibrosarcoma Límite: Animals Idioma: En Revista: J Microencapsul Asunto de la revista: FARMACIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido