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In Vitro Study of the Expression of CD1, CD14, CD25, CD30, CD35, CD95 Receptors by Macrophages of Mice Infected with Mycobacterium tuberculosis.
Il'in, D A; Shkurupy, V A; Akhramenko, E S.
Afiliación
  • Il'in DA; Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. ilindenis.ilin@yandex.ru.
  • Shkurupy VA; Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
  • Akhramenko ES; Novosibirsk State Medical University, Ministry of the Health of the Russian Federation, Novosibirsk, Russia.
Bull Exp Biol Med ; 172(1): 42-45, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34796425
In cultures of peritoneal macrophages (MP) of male BALB/c mice infected with Mycobacterium tuberculosis from the BCG vaccine, the expression of CD1, CD14, CD25, CD30, CD35, and CD95 receptors was studied in vitro 3 months after infection. In MP cultures from intact and infected mice, mononuclear MP predominated (96 and 92%, respectively). Bi- and trinuclear MP in MP cultures from control and infected mice constituted 4 and 8.3% of all MP, respectively. In the cultures of both groups, no obvious correlations between the number of MP expressing CD-receptors and number of nuclei in these cells were found, but the expression of CD14 receptor was more often noted. In cultures from infected animals, hypertrophied MP and enhanced (by several times) expression of all CD-receptors were observed. The increase in the expression of CD-receptor can be determined by activation of plastic processes in hypertrophied MP (in epithelioid and in numerically insignificant polynuclear MP), which is due to the phenomenon of prolonged M. tuberculosis persistence in the vacuolar apparatus of these cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Receptores de Citocinas / Macrófagos Peritoneales / Antígenos CD1 / Mycobacterium tuberculosis Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Receptores de Citocinas / Macrófagos Peritoneales / Antígenos CD1 / Mycobacterium tuberculosis Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos