Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells.

Bar, Shiran; Vershkov, Dan; Keshet, Gal; Lezmi, Elyad; Meller, Naama; Yilmaz, Atilgan; Yanuka, Ofra; Nissim-Rafinia, Malka; Meshorer, Eran; Eldar-Geva, Talia; Benvenisty, Nissim

Bar, Shiran; Vershkov, Dan; Keshet, Gal; Lezmi, Elyad; Meller, Naama; Yilmaz, Atilgan; Yanuka, Ofra; Nissim-Rafinia, Malka; Meshorer, Eran; Eldar-Geva, Talia; Benvenisty, Nissim.

Afiliación

Bar S; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Vershkov D; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Keshet G; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Lezmi E; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Meller N; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Yilmaz A; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Yanuka O; The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Nissim-Rafinia M; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Meshorer E; Edmond and Lily Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Eldar-Geva T; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.
Benvenisty N; Edmond and Lily Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Nat Commun ; 12(1): 6718, 2021 11 18.

Article en En | MEDLINE | ID: mdl-34795250

Asunto(s)

Sistemas CRISPR-Cas; Regulación de la Expresión Génica; Impresión Genómica; Haploidia; Células Madre Embrionarias Humanas/metabolismo; Animales; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Células Cultivadas; Secuenciación de Inmunoprecipitación de Cromatina/métodos; ADN (Citosina-5-)-Metiltransferasa 1/genética; ADN (Citosina-5-)-Metiltransferasa 1/metabolismo; Metilación de ADN; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Células HeLa; Células Madre Embrionarias Humanas/citología; Humanos; Sistema de Señalización de MAP Quinasas/genética; Masculino; Partenogénesis/genética; Proteínas de Unión al ARN/genética; Proteínas de Unión al ARN/metabolismo; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Espermatogénesis/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Impresión Genómica / Sistemas CRISPR-Cas / Células Madre Embrionarias Humanas / Haploidia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido

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