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Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV.
Duarte, Geraldo; Muresan, Petronella; Ward, Shawn; Laimon, Lauren; Pelton, Stephen I; Canniff, Jennifer; Golner, Amanda; Bone, Frederic; Newton, Lassallete; Fenton, Terence; Coutinho, Conrado M; João, Esau C; Santos, Breno R; Pilotto, Jose H; Oliveira, Ricardo H; Pinto, Jorge A; Machado, Elizabeth S; Kreitchman, Regis; Chakhtoura, Nahida; Mussi-Pinhata, Marisa M; Weinberg, Adriana.
Afiliación
  • Duarte G; Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
  • Muresan P; Frontier Science Foundation, Brookline, Massachusetts, USA.
  • Ward S; Frontier Science Foundation, Brookline, Massachusetts, USA.
  • Laimon L; Westat, Rockville, Maryland, USA.
  • Pelton SI; Boston University School of Medicine, Boston, Massachusetts, USA.
  • Canniff J; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Golner A; Frontier Science Foundation, Buffalo, New York, USA.
  • Bone F; Frontier Science Foundation, Buffalo, New York, USA.
  • Newton L; Westat, Rockville, Maryland, USA.
  • Fenton T; Frontier Science Foundation, Brookline, Massachusetts, USA.
  • Coutinho CM; Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
  • João EC; Hospital dos Servidores Estaduais, Rio de Janeiro, Brazil.
  • Santos BR; Hospital Nossa Senhora da Conceicao, Porto Alegre, Brazil.
  • Pilotto JH; Hospital Geral de Nova Iguaçu, Rio de Janeiro, Brazil.
  • Oliveira RH; Instituto de Puericultura e Pediatra Matagão Gesteira, Rio de Janeiro, Brazil.
  • Pinto JA; School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Machado ES; Instituto de Puericultura e Pediatra Matagão Gesteira, Rio de Janeiro, Brazil.
  • Kreitchman R; Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
  • Chakhtoura N; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
  • Mussi-Pinhata MM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.
  • Weinberg A; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
J Infect Dis ; 225(6): 1021-1031, 2022 03 15.
Article en En | MEDLINE | ID: mdl-34791324
BACKGROUND: Pneumococcal vaccination is recommended in people with HIV, prioritizing PCV. We compared the immunogenicity of PCV-10 and PPV-23 administered antepartum or postpartum. METHODS: This double-blind study randomized 346 pregnant women with HIV on antiretrovirals to PCV-10, PPV-23, or placebo at 14-34 weeks gestational age. Women who received placebo antepartum were randomized at 24 weeks postpartum to PCV-10 or PPV-23. Antibodies against 7 serotypes common to both vaccines and 1 serotype only in PPV-23 were measured by ELISA/chemiluminescence; B- and T-cell responses to serotype 1 by FLUOROSPOT; and plasma cytokines/chemokines by chemiluminescence. RESULTS: Antibody responses were higher after postpartum versus antepartum vaccination. PCV-10 generated lower antibody levels than PPV-23 against 4 and higher against 1 of 7 common serotypes. Additional factors associated with high postvaccination antibody concentrations were high prevaccination antibody concentrations and CD4+ cells; low CD8+ cells and plasma HIV RNA; and several plasma cytokines/chemokines. Serotype 1 B- and T-cell memory did not increase after vaccination. CONCLUSIONS: Antepartum immunization generated suboptimal antibody responses, suggesting that postpartum booster doses may be beneficial and warrant further studies. Considering that PCV-10 and PPV-23 had similar immunogenicity, but PPV-23 covered more serotypes, use of PPV-23 may be prioritized in women with HIV on antiretroviral therapy. CLINICAL TRAILS REGISTRATION: NCT02717494.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Infecciones por VIH Tipo de estudio: Clinical_trials Límite: Female / Humans / Pregnancy Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Infecciones por VIH Tipo de estudio: Clinical_trials Límite: Female / Humans / Pregnancy Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos