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Analgesic and Anti-Inflammatory Activities of Sophocarpine from Sophora viciifolia Hance.
Wang, F L; Wang, H; Wang, J H; Wang, D X; Gao, Y; Yang, B; Yang, H J; Ji, Y B; Xin, G S.
Afiliación
  • Wang FL; School of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, China.
  • Wang H; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China.
  • Wang JH; Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang Province, Harbin 150076, China.
  • Wang DX; School of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, China.
  • Gao Y; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China.
  • Yang B; Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang Province, Harbin 150076, China.
  • Yang HJ; School of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, China.
  • Ji YB; Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China.
  • Xin GS; Key Laboratory for Drug Research on Prevention and Treatment of Geriatric Diseases of Heilongjiang Province, Harbin 150076, China.
Biomed Res Int ; 2021: 8893563, 2021.
Article en En | MEDLINE | ID: mdl-34790825
Sophora viciifolia Hance is an edible plant used in traditional Chinese medicine. Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora viciifolia Hance. Here, we study the analgesic and anti-inflammatory effects, as well as the acute toxicity of sophocarpine from Sophora viciifolia Hance in mice. Sophocarpine (20, 40, and 80 mg/kgbw) significantly prolonged the delay period before a hot plate reaction occurred (all P < 0.05), and the delay before a tail-flick response was induced by a warm bath (P < 0.05; P < 0.01). Sophocarpine (40, 80 mg/kg) resulted in dose-dependent inhibition of the writhing reaction induced by acetic acid in mice (P < 0.05; P < 0.001, respectively). Sophocarpine (80 mg/kg) reduced the total duration of a formalin-induced pain response (P < 0.05). Sophocarpine prolonged the foot-licking latency of mice after the hot plate reaction, and this effect was antagonized by calcium chloride and enhanced by verapamil. Sophocarpine (20, 40, and 80 mg/kg) significantly inhibited xylene-induced ear edema (P < 0.01; P < 0.001; P < 0.001, respectively) and the penetration of acetic acid-induced dye into the peritoneal cavity (P < 0.01; P < 0.01; P < 0.001, respectively). It also reduced the levels of proinflammatory cytokine interleukin (IL)-1ß, IL-6, and prostaglandin E2 (P < 0.05, P < 0.01, P < 0.001) and those of serum nitric oxide (P < 0.05). The results of this study suggest that sophocarpine possesses certain analgesic and anti-inflammatory activities, which may be related to calcium and inhibition of the secretion of inflammatory factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Alcaloides Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Alcaloides Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos