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Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field.
Visacri, Marília B; Nicoletti, Aline S; Pincinato, Eder C; Loren, Pía; Saavedra, Nicolás; Saavedra, Kathleen; Salazar, Luis A; Moriel, Patricia.
Afiliación
  • Visacri MB; Department of Pharmacology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil.
  • Nicoletti AS; Department of Pharmacology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil.
  • Pincinato EC; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil.
  • Loren P; Center of Molecular Biology & Pharmacogenetics, Scientific & Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile.
  • Saavedra N; Center of Molecular Biology & Pharmacogenetics, Scientific & Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile.
  • Saavedra K; Center of Molecular Biology & Pharmacogenetics, Scientific & Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile.
  • Salazar LA; Center of Molecular Biology & Pharmacogenetics, Scientific & Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile.
  • Moriel P; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, 13083-871, Brazil.
Biomark Med ; 15(18): 1785-1795, 2021 12.
Article en En | MEDLINE | ID: mdl-34784802
Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature search of nine databases was carried out for studies published before 13 June 2021 that described dysregulated miRNAs in cells or animals infected by SARS-CoV-2 or in patients with COVID-19. Two independent reviewers selected the studies and extracted data; disagreements were resolved by a third reviewer. Results: Twenty studies were included in this scoping review; results suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. miRNAs appear to play key roles in viral replication, proliferation of infected cells, immune response, inflammation and cardiovascular dysfunction. Conclusion: This review provides insights into the role of miRNAs as biomarkers in COVID-19 and the current status and future directions for research in this field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido