Towards multi-target antidiabetic agents: In vitro and in vivo evaluation of 3,5-disubstituted indolin-2-one derivatives as novel &#945;-glucosidase inhibitors.

Klochkov, Vladlen G; Bezsonova, Elena N; Dubar, Meriam; Melekhina, Daria D; Temnov, Victor V; Zaryanova, Ekaterina V; Lozinskaya, Natalia A; Babkov, Denis A; Spasov, Alexander A

Towards multi-target antidiabetic agents: In vitro and in vivo evaluation of 3,5-disubstituted indolin-2-one derivatives as novel α-glucosidase inhibitors.

Klochkov, Vladlen G; Bezsonova, Elena N; Dubar, Meriam; Melekhina, Daria D; Temnov, Victor V; Zaryanova, Ekaterina V; Lozinskaya, Natalia A; Babkov, Denis A; Spasov, Alexander A.

Afiliación

Klochkov VG; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd 400131, Russia.
Bezsonova EN; Lomonosov Moscow State University, Department of Chemistry, Leninskie gory St., 1, Moscow 119234, Russia.
Dubar M; Lomonosov Moscow State University, Department of Chemistry, Leninskie gory St., 1, Moscow 119234, Russia.
Melekhina DD; Lomonosov Moscow State University, Department of Chemistry, Leninskie gory St., 1, Moscow 119234, Russia.
Temnov VV; Lomonosov Moscow State University, Department of Chemistry, Leninskie gory St., 1, Moscow 119234, Russia.
Zaryanova EV; Lomonosov Moscow State University, Department of Chemistry, Leninskie gory St., 1, Moscow 119234, Russia.
Lozinskaya NA; Lomonosov Moscow State University, Department of Chemistry, Leninskie gory St., 1, Moscow 119234, Russia. Electronic address: natalylozinskaya@mail.ru.
Babkov DA; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd 400131, Russia; Scientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya St. 39, Volgograd 400087, Russia. Electronic address: dababkov@volgmed.ru.
Spasov AA; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Pavshikh Bortsov Sq. 1, Volgograd 400131, Russia; Scientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya St. 39, Volgograd 400087, Russia.

Bioorg Med Chem Lett ; 55: 128449, 2022 01 01.

Article en En | MEDLINE | ID: mdl-34780899

Asunto(s)

Diabetes Mellitus Tipo 2/tratamiento farmacológico; Inhibidores de Glicósido Hidrolasas/farmacología; Hipoglucemiantes/farmacología; Indoles/farmacología; alfa-Glucosidasas/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Relación Dosis-Respuesta a Droga; Inhibidores de Glicósido Hidrolasas/síntesis química; Inhibidores de Glicósido Hidrolasas/química; Humanos; Hipoglucemiantes/síntesis química; Hipoglucemiantes/química; Indoles/síntesis química; Indoles/química; Modelos Moleculares; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

Diabetes mellitus; Indolin-2-one; Oxindoles; α-Glucosidase inhibitors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Alfa-Glucosidasas / Inhibidores de Glicósido Hidrolasas / Hipoglucemiantes / Indoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido

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