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Exploiting the antiviral potential of intermetallic nanoparticles.
Matharu, Rupy Kaur; Cheong, Yuen-Ki; Ren, Guogang; Edirisinghe, Mohan; Ciric, Lena.
Afiliación
  • Matharu RK; Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE UK.
  • Cheong YK; Department of Civil, Environmental and Geomatic Engineering, University College London, Gower Street, London, WC1E 6BT UK.
  • Ren G; School of Engineering and Computer Science, University of Hertfordshire, Hatfield, AL10 9AB UK.
  • Edirisinghe M; School of Engineering and Computer Science, University of Hertfordshire, Hatfield, AL10 9AB UK.
  • Ciric L; Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE UK.
Emergent Mater ; 5(4): 1251-1260, 2022.
Article en En | MEDLINE | ID: mdl-34778706
Viral pandemic outbreaks cause a significant burden on global health as well as healthcare expenditure. The use of antiviral agents not only reduces the spread of viral pathogens but also diminishes the likelihood of them causing infection. The antiviral properties of novel copper-silver and copper-zinc intermetallic nanoparticles against Escherichia coli bacteriophage MS2 (RNA virus) and Escherichia coli bacteriophage T4 (DNA virus) are presented. The intermetallic nanoparticles were spherical in shape and were between 90 and 120 nm. Antiviral activity was assessed at concentrations ranging from 0.05 to 2.0 wt/v% for 3 and 24 h using DNA and RNA virus model organisms. Both types of nanoparticles demonstrated strong potency towards RNA viruses (> 89% viral reduction), whilst copper-silver nanoparticles were slightly more toxic towards DNA viruses when compared to copper-zinc nanoparticles. Both nanoparticles were then incorporated into polymeric fibres (carrier) to investigate their antiviral effectiveness when composited into polymeric matrices. Fibres containing copper-silver nanoparticles exhibited favourable antiviral properties, with a viral reduction of 75% after 3 h of exposure. The excellent antiviral properties of the intermetallic nanoparticles reported in this study against both types of viruses together with their unique material properties can make them significant alternatives to conventional antiviral therapies and decontamination agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Emergent Mater Año: 2022 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Emergent Mater Año: 2022 Tipo del documento: Article Pais de publicación: Suiza