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Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review.
Zhang, Ruobing; Guo, Tiantian; Ji, Lulin; Yin, Yirui; Feng, Shuitu; Lu, Weihong; Zhang, Fei; Zhu, Maoshu; Liu, Shugang; Jiang, Jinhua; Zeng, Fanwei.
Afiliación
  • Zhang R; Organoid Research Center, Xiamen Broad Creation Biomedical Institute, Xiamen, China.
  • Guo T; Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China.
  • Ji L; Organoid Research Center, Xiamen Broad Creation Biomedical Institute, Xiamen, China.
  • Yin Y; Department of General Surgery, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
  • Feng S; Oncology Department, Xiamen Haicang Hospital, Xiamen, China.
  • Lu W; Department of Obstetrics and Gynecology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
  • Zhang F; Department of Obstetrics and Gynecology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
  • Zhu M; Central Lab, The Fifth Hospital of Xiamen, Xiamen, China.
  • Liu S; Department of Traditional Chinese Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Jiang J; Department of Interventional Oncology, Renji Hospital School of Medicine, Shanghai Jiaotong University, Shanghai, China.
  • Zeng F; Organoid Research Center, Xiamen Broad Creation Biomedical Institute, Xiamen, China.
Front Oncol ; 11: 716339, 2021.
Article en En | MEDLINE | ID: mdl-34778032
Human gastrointestinal cancer (e.g., gastric cancer and colorectal cancer) has been a leading cause of cancer-related deaths worldwide and has imposed a great threat to the public health. Although early-stage gastrointestinal cancer can be effectively treated by surgery, followed by postoperative chemotherapy, patients with advanced gastrointestinal cancer often exhibit poor prognosis and cancer relapse due to the absence of effective personalized treatment strategies. Patient-derived cancer organoid technology has been rapidly developed in recent years, and its emergence has opened up an unprecedented approach to model human cancers in vitro. Patient-derived cancer organoids involve the ex vivo culture of fragments of freshly resected human tumors that retain the histological features of original tumors. This review thoroughly discussed the evolutionary process of human gastrointestinal organoids cultured since 2009, and highlighted the potentials of patient-derived cancer organoids in clinical management of gastrointestinal cancer in terms of advances achieved in cancer modelling compared with conventional modelling methods, high-throughput drug screening, and development of personalized treatment selection. Additionally, the current limitations of patient-derived cancer organoids and the potential solutions to overcome these problems were summarized.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza