Whole genome sequencing facilitates intragenic variant interpretation following modifier screening in C. elegans.

Jean, Francesca; Stasiuk, Susan; Maroilley, Tatiana; Diao, Catherine; Galbraith, Andrew; Tarailo-Graovac, Maja

Jean, Francesca; Stasiuk, Susan; Maroilley, Tatiana; Diao, Catherine; Galbraith, Andrew; Tarailo-Graovac, Maja.

Afiliación

Jean F; Departments of Biochemistry, Molecular Biology and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Stasiuk S; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
Maroilley T; Departments of Biochemistry, Molecular Biology and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Diao C; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
Galbraith A; Departments of Biochemistry, Molecular Biology and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Tarailo-Graovac M; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.

BMC Genomics ; 22(1): 820, 2021 Nov 13.

Article en En | MEDLINE | ID: mdl-34773966

Asunto(s)

Proteínas de Caenorhabditis elegans; Caenorhabditis elegans; Alelos; Animales; Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/genética; Mutación; Proteínas Quinasas/genética; Secuenciación Completa del Genoma

Palabras clave

C. elegans; CRISPR/Cas9; Intragenic modifier; Mutagenesis screen; Whole genome sequencing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caenorhabditis elegans / Proteínas de Caenorhabditis elegans Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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