Your browser doesn't support javascript.
loading
Long Term Efficacy and Assessment of Tumor Response of Transarterial Chemoembolization in Neuroendocrine Liver Metastases: A 15-Year Monocentric Experience.
Touloupas, Caroline; Faron, Matthieu; Hadoux, Julien; Deschamps, Frédéric; Roux, Charles; Ronot, Maxime; Yevich, Steven; Joskin, Julien; Gelli, Maximiliano; Barbé, Rémy; Lamartina, Livia; Tissot, Hubert; Scoazec, Jean-Yves; Malka, David; Ducreux, Michel; Baudin, Eric; de Baère, Thierry; Tselikas, Lambros.
Afiliación
  • Touloupas C; Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), F-94805 Villejuif, France.
  • Faron M; Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), F-94805 Villejuif, France.
  • Hadoux J; INSERM U1018 OncoStat, CESP, Universtié Paris-Sud, F-94805 Villejuif, France.
  • Deschamps F; Gustave Roussy, Cancer Medicine Department, F-94805 Villejuif, France.
  • Roux C; Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), F-94805 Villejuif, France.
  • Ronot M; Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), F-94805 Villejuif, France.
  • Yevich S; Beaujon Hospital, Department of Radiology, Université de Paris, APHP.Nord, F-92110 Clichy, France.
  • Joskin J; MD Anderson Cancer Center, Medical Imaging Department, University of Texas, Houston, TX 77030, USA.
  • Gelli M; Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), F-94805 Villejuif, France.
  • Barbé R; Gustave Roussy, Département d'Anesthésie, Chirurgie et Interventionnel (DACI), F-94805 Villejuif, France.
  • Lamartina L; Gustave Roussy, Medical Imaging Department, F-94805 Villejuif, France.
  • Tissot H; Gustave Roussy, Cancer Medicine Department, F-94805 Villejuif, France.
  • Scoazec JY; Gustave Roussy, Medical Imaging Department, F-94805 Villejuif, France.
  • Malka D; Gustave Roussy, Department of Medical Biology and Pathology, F-94805 Villejuif, France.
  • Ducreux M; Faculty of Medicine, Paris-Saclay University, F-94276 Le Kremlin Bicêtre, France.
  • Baudin E; Gustave Roussy, Cancer Medicine Department, F-94805 Villejuif, France.
  • de Baère T; Gustave Roussy, Cancer Medicine Department, F-94805 Villejuif, France.
  • Tselikas L; Faculty of Medicine, Paris-Saclay University, F-94276 Le Kremlin Bicêtre, France.
Cancers (Basel) ; 13(21)2021 Oct 26.
Article en En | MEDLINE | ID: mdl-34771531
BACKGROUND: transarterial chemoembolization (TACE) is an established treatment for neuroendocrine tumor (NET) liver metastases. The aim was to evaluate the long-term treatment efficacy of TACE for NET liver metastases, and correlate imaging response with survival. METHODS: this IRB-approved, single-center, retrospective study evaluated all TACE procedures performed for NET liver metastases from 2003-2017 for imaging tumor response (RECIST and mRECIST), time to liver progression (TTLP), time to untreatable progression with TACE (TTUP), and overall survival (OS). Patient, tumor, and treatment characteristics were analyzed as prognostic factors. Survival curves according to the Kaplan-Meier method were compared by Log-rank test. Tumor responses according to RECIST and mRECIST were correlated with OS. RESULTS: 555 TACE procedures were performed in 202 NET patients (38% grade 1, 60% grade 2) with primary tumors originating from pancreas, small bowel, and lung (39, 26, and 22% respectively). Median follow-up was 8.2 years (90-139 months). Median TTLP and TTUP were 19.3 months (95%CI 16.3-22.3) and 26.2 months (95%CI 22.3-33.1), respectively. Median OS was 5.3 years (95%CI 4.2-6.7), and was higher among mRECIST responders (80.5 months; 95%CI 64.6-89.8) than in non-responders (39.6 months; 95%CI = 32.8-60.2; p < 0.001). In multivariable analysis, age, tumor grade and liver involvement predicted worse OS, whereas administration of somatostatin analogs correlated with improved OS. CONCLUSION: TACE for NET liver metastases provides objective response and sustained local disease control rates. RECIST and mRECIST responses correlate with OS.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza