Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway.

Tan, Xiang-Peng; He, Yan; Huang, Yun-Na; Zheng, Can-Can; Li, Jun-Qi; Liu, Qin-Wen; He, Ming-Liang; Li, Bin; Xu, Wen-Wen

Tan, Xiang-Peng; He, Yan; Huang, Yun-Na; Zheng, Can-Can; Li, Jun-Qi; Liu, Qin-Wen; He, Ming-Liang; Li, Bin; Xu, Wen-Wen.

Afiliación

Tan XP; MOE Key Laboratory of Tumor Molecular Biology National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology and The First Affiliated Hospital of Jinan University Jinan University Guangzhou China.
He Y; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University Guangzhou China.
Huang YN; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University Guangzhou China.
Zheng CC; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health Engineering College of Life Science and Technology Jinan University Guangzhou China.
Li JQ; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University Guangzhou China.
Liu QW; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University Guangzhou China.
He ML; Department of Biomedical Sciences City University of Hong Kong Hong Kong China.
Li B; MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health Engineering College of Life Science and Technology Jinan University Guangzhou China.
Xu WW; MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University Guangzhou China.

MedComm (2020) ; 2(3): 453-466, 2021 Sep.

Article en En | MEDLINE | ID: mdl-34766155

Palabras clave

PI3K/Akt/mTOR signaling pathway; colorectal cancer; drug repurposing; lomerizine 2HCl; protective autophagy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedComm (2020) Año: 2021 Tipo del documento: Article Pais de publicación: China

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