Enantioselective palladaelectro-catalyzed C-H olefinations and allylations for N-C axial chirality.
Chem Sci
; 12(42): 14182-14188, 2021 Nov 03.
Article
en En
| MEDLINE
| ID: mdl-34760203
Enantioselective palladaelectro-catalyzed C-H alkenylations and allylations were achieved with easily-accessible amino acids as transient directing groups. This strategy provided access to highly enantiomerically-enriched N-C axially chiral scaffolds under exceedingly mild conditions. The synthetic utility of our strategy was demonstrated by a variety of alkenes, while the versatility of our approach was reflected by atroposelective C-H allylations. Computational studies provided insights into a facile C-H activation by a seven-membered palladacycle.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Reino Unido