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Changes in paediatric respiratory infections at a UK teaching hospital 2016-2021; impact of the SARS-CoV-2 pandemic.
Lumley, Sheila F; Richens, Nicholas; Lees, Emily; Cregan, Jack; Kalimeris, Elizabeth; Oakley, Sarah; Morgan, Marcus; Segal, Shelley; Dawson, Moya; Walker, A Sarah; Eyre, David W; Crook, Derrick W; Beer, Sally; Novak, Alex; Stoesser, Nicole E; Matthews, Philippa C.
Afiliación
  • Lumley SF; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford OX1 3SY, UK. Electronic address: sheila.lumley@trinity.ox.ac.uk.
  • Richens N; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Lees E; Department of Paediatrics, University of Oxford, Oxford UK.
  • Cregan J; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford OX1 3SY, UK.
  • Kalimeris E; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Oakley S; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Morgan M; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Segal S; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Dawson M; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Walker AS; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford OX1 3SY, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University o
  • Eyre DW; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK; Nuffield Department of Pop
  • Crook DW; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford OX1 3SY, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; NIHR Health Protection Research Unit in Healthcare A
  • Beer S; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Novak A; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK.
  • Stoesser NE; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford OX1 3SY, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; NIHR Health Protection Research Unit in Healthcare A
  • Matthews PC; NHS Foundation Trust, Oxford University Hospitals, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford OX1 3SY, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; NIHR Health Protection Research Unit in Healthcare A
J Infect ; 84(1): 40-47, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34757137
Objective To describe the impact of the SARS-CoV-2 pandemic on the incidence of paediatric viral respiratory tract infection in Oxfordshire, UK. Methods Data on paediatric Emergency Department (ED) attendances (0-15 years inclusive), respiratory virus testing, vital signs and mortality at Oxford University Hospitals were summarised using descriptive statistics. Results Between 1-March-2016 and 30-July-2021, 155,056 ED attendances occurred and 7,195 respiratory virus PCRs were performed. Detection of all pathogens was suppressed during the first national lockdown. Rhinovirus and adenovirus rates increased when schools reopened September-December 2020, then fell, before rising in March-May 2021. The usual winter RSV peak did not occur in 2020/21, with an inter-seasonal rise (32/1,000 attendances in 0-3 yr olds) in July 2021. Influenza remained suppressed throughout. A higher paediatric early warning score (PEWS) was seen for attendees with adenovirus during the pandemic compared to pre-pandemic (p = 0.04, Mann-Witney U test), no other differences in PEWS were seen. Conclusions SARS-CoV-2 caused major changes in the incidence of paediatric respiratory viral infection in Oxfordshire, with implications for clinical service demand, testing strategies, timing of palivizumab RSV prophylaxis, and highlighting the need to understand which public health interventions are most effective for preventing respiratory virus infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Infecciones por Virus Sincitial Respiratorio / COVID-19 Límite: Child / Humans País/Región como asunto: Europa Idioma: En Revista: J Infect Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Infecciones por Virus Sincitial Respiratorio / COVID-19 Límite: Child / Humans País/Región como asunto: Europa Idioma: En Revista: J Infect Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido