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Genetic Polymorphisms in NLRP3 Inflammasome-Associated Genes in Patients with B-Cell Non-Hodgkin's Lymphoma.
Liu, Zhi-He; Zhang, Lin; Jing, Fan-Jing; Xiao, Shu-Xin; Gao, Yan; Bian, Hai-Yan; Zhao, Xia.
Afiliación
  • Liu ZH; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
  • Zhang L; Laboratory of Molecular Diagnosis and Regenerative Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
  • Jing FJ; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
  • Xiao SX; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
  • Gao Y; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
  • Bian HY; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
  • Zhao X; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People's Republic of China.
J Inflamm Res ; 14: 5687-5697, 2021.
Article en En | MEDLINE | ID: mdl-34754215
PURPOSE: The role of NLRP3 inflammasome in the progression of many diseases has been increasingly recognized. However, the function of this molecular assembly in the development and progression of B-cell non-Hodgkin's lymphoma remains unclear. PATIENTS AND METHODS: In this study, we investigated the polymorphisms in the NLRP3 inflammasome associated genes in 281 patients with B-cell non-Hodgkin's lymphoma and 385 age- and gender-matched healthy controls. RESULTS: We found that IL-18 (rs1946518) and NFκB-94 ins/del (rs28362491) contributed to susceptibility to B-cell non-Hodgkin's lymphoma. Specifically, the allele "G" in IL-18 (rs1946518) and allele "ins" in NFκB-94 ins/del (rs28362491) were significantly associated with the risk of disease. The AA genotype of CARD8 (rs2043211) and the higher level of serum lactate dehydrogenase (LDH) led to statistically poorer B-cell non-Hodgkin's lymphoma survival. Less frequent genotype TT of CARD8 (rs2043211) was observed in patients with higher LDH level, clinical stages III-IV of disease, and IPI 3-5, although the relationship did not reach statistical significance. However, IPI is an independent prognostic factor for B-cell non-Hodgkin's lymphoma. CONCLUSION: IL-18 (rs1946518) and NFκB-94 ins/del (rs28362491) gene polymorphisms appear to be the factors influencing the risk of B-cell non-Hodgkin's lymphoma. CARD8 (rs2043211) polymorphisms are important factors for the survival of patients with this disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Inflamm Res Año: 2021 Tipo del documento: Article Pais de publicación: Nueva Zelanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Inflamm Res Año: 2021 Tipo del documento: Article Pais de publicación: Nueva Zelanda