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Risks and benefits of systematic lymphadenectomy during interval debulking surgery for advanced high grade serous ovarian cancer.
Benoit, Louise; Koual, Meriem; Le Frère-Belda, Marie-Aude; Zerbib, Jonathan; Fournier, Laure; Nguyen-Xuan, Huyen-Thu; Delanoy, Nicolas; Bentivegna, Enrica; Bats, Anne-Sophie; Azaïs, Henri.
Afiliación
  • Benoit L; Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France; Paris University, Faculty of Medicine, Paris, France; INSERM UMR-S 1124, Université de Paris, Centre Universitaire des Saint-Père, Paris, France. Electronic address: louise.benoit@ap
  • Koual M; Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France; Paris University, Faculty of Medicine, Paris, France; INSERM UMR-S 1124, Université de Paris, Centre Universitaire des Saint-Père, Paris, France.
  • Le Frère-Belda MA; Pathology Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France.
  • Zerbib J; Radiology Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France.
  • Fournier L; Radiology Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France.
  • Nguyen-Xuan HT; Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France; Paris University, Faculty of Medicine, Paris, France.
  • Delanoy N; Oncology Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France.
  • Bentivegna E; Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France; Paris University, Faculty of Medicine, Paris, France.
  • Bats AS; Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France; Paris University, Faculty of Medicine, Paris, France; INSERM UMR-S 1147, Université de Paris, Centre de Recherche des Cordeliers, Paris, France.
  • Azaïs H; Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, APHP. Centre, Paris, France; Paris University, Faculty of Medicine, Paris, France; INSERM UMR-S 1147, Université de Paris, Centre de Recherche des Cordeliers, Paris, France.
Eur J Surg Oncol ; 48(1): 275-282, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34753619
BACKGROUND: Lymphadenectomy is debated in patients with ovarian cancer. The aim of our study was to evaluate the impact of lymphadenectomy in patients with high-grade serous ovarian cancer receiving neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). METHODS: A retrospective, unicentric study including all patients undergoing NACT and IDS was carried out from 2005 to 2018. Patients with and without lymphadenectomy were compared in terms of recurrence free survival (RFS), overall survival (OS), and complication rates. RESULTS: We included 203 patients. Of these, 133 had a lymphadenectomy (65.5%) and 77 had involved nodes (57.9%). Patients without a lymphadenectomy were older, had a more extensive disease and less complete CRS. No differences were noted between the lymphadenectomy and no lymphadenectomy group concerning 2-year RFS (47.4% and 48.6%, p = 0.87, respectively) and 5-year OS (63.2% versus 58.6%, p = 0.41, respectively). Post-operative complications tended to be more frequent in the lymphadenectomy group (18.57% versus 31.58%, p = 0.09). In patients with a lymphadenectomy, survival was significantly altered if the nodes were involved (positive nodes: 2-year RFS 42.5% and 5-year OS 49.4%, negative nodes: 2-year RFS 60.7% and 5-year OS 82.2%, p = 0.03 and p < 0.001, respectively). CONCLUSION: Lymphadenectomy during IDS does not improve survival and increases post-operative complications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Complicaciones Posoperatorias / Neoplasias Quísticas, Mucinosas y Serosas / Procedimientos Quirúrgicos de Citorreducción / Carcinoma Epitelial de Ovario / Escisión del Ganglio Linfático Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Complicaciones Posoperatorias / Neoplasias Quísticas, Mucinosas y Serosas / Procedimientos Quirúrgicos de Citorreducción / Carcinoma Epitelial de Ovario / Escisión del Ganglio Linfático Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido